Bioavailability of Hydroxytyrosol From Olive Watery Extract Supplements

Launched by DAACRO · May 3, 2021

Keywords

ClinConnect Summary

Background:

Hydroxytyrosol is a phenolic phytochemical naturally occurring in olives with potential antioxidant, anti-inflammatory, and health benefits mainly related with cardiovascular diseases \[for review see Covas et al., 2015\]. OliPhenolia® bitter and OliPhenolia® are two food supplements resulting from the liquid by-product generated during olive oil production, that are rich in olive polyphenols, mainly hydroxytyrosol. Hydroxytyrosol and its derivatives (tyrosol and oleuropein) are present in higher levels in the watery extracts from olives when compared with the oil fraction.

Mo...

Gender

MALE

Eligibility criteria

• Inclusion Criteria:
• • Self-reported healthy men aged 21-50,
• • subject has an adequate understanding of the study and signs the informed consent to participate in the study,
• • willingness to follow dietary and physical activity restrictions during study participation,
• • body mass index range: \>18.5 and \<29.9 kg/m2.
• Exclusion Criteria:
• • Any known allergies to IPs (olives and their derivates),
• • any acute and chronic diseases (e.g. diagnosis of diabetes mellitus, hypertension, dyslipidemia or other cardiometabolic disorders, diagnosed hepatic, renal, or cardiovascular disease),
• • any kind of eating disorders,
• • not fluent in German,
• • any previous (last 14 days prior to screening) and any ongoing pharmacological therapy (e.g. any medication, vaccination, infusion),
• • any intake of nutritional supplements,
• • any known addiction to drugs and/or alcohol,
• • smoker,
• • Investigator or physician doubts truthfulness of self-reported health information.