The OPERa Study: Evaluating QoL After Rectal Cancer Surgery

Launched by JEWISH GENERAL HOSPITAL · May 17, 2021

Keywords

ClinConnect Summary

The OPERa Study is a clinical trial aimed at understanding how rectal cancer surgery affects the quality of life (QoL) of patients in North America. Specifically, it will look at issues like bowel dysfunction, sexual and urinary problems, and emotional distress that can arise after a common surgery called restorative proctectomy. Many patients experience long-term bowel issues, known as Low Anterior Resection Syndrome (LARS), which can lead to challenges such as frequent trips to the bathroom, incontinence, and difficulty with bowel movements. This study will gather important data on these issues over three years to better support patients after treatment.

To participate in this study, individuals must be over 18 years old and diagnosed with rectal cancer that meets certain criteria. They should be planning to undergo restorative proctectomy or specific types of treatment without surgery. Participants will be recruited from 20 different sites and will complete questionnaires about their health and well-being at various points during their treatment and recovery. This research aims to provide new insights that could help improve care and support for rectal cancer survivors in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients \>18 years with histopathologically confirmed adenocarcinoma of the rectum, defined as tumor ≤15cm from the anal verge who are planned for RP ± neoadjuvant treatment or WW (CRT alone without surgery).
• Exclusion Criteria:
• • Metastatic disease at diagnosis;
• • Planned for abdominoperineal resection (APR), low Hartmann's or pelvic exenteration (PE);
• • Cannot be contacted by telephone;
• • Unable to read and comprehend English or French;
• • Unable to give clear and informed consent.