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Search / Trial NCT04894864

Opioid Free Anesthesia-Analgesia Strategy and Surgical Stress in Elective Open Abdominal Aortic Aneurysm Repair

Launched by UNIVERSITY OF CRETE · May 16, 2021

Trial Information

Current as of July 09, 2025

Recruiting

Keywords

Opioid Free Anesthesia Analgesia Cytokines Opioid Based Anesthesia Analgesia Haemodynamic Stability Open Abdominal Aortic Aneurysm Repair Immunomodulation Inflammatory Markers

ClinConnect Summary

This clinical trial is exploring a new approach to anesthesia for patients undergoing elective open surgery to repair an abdominal aortic aneurysm, which is a serious condition affecting the blood vessels. The trial aims to see if using an opioid-free anesthesia strategy can reduce the body’s stress response to surgery and improve recovery outcomes compared to traditional methods that use opioids. Participants in this study will receive a combination of different medications that work in various ways to manage pain and reduce inflammation during and after the surgery.

To be eligible for this trial, participants should be between 40 and 85 years old, and they must be scheduled for elective surgery to repair an abdominal aortic aneurysm. However, individuals with certain health conditions, such as active infections, cancer, or those who are immunocompromised, cannot participate. If you decide to take part in this study, you can expect to receive careful monitoring and support throughout the surgical process, with the hope of experiencing less pain and a quicker recovery.

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • 1. Patient Consent
  • 2. Age between 40 and 85 years old
  • 3. Patients undergoing Elective Open Abdominal Aortic Infrarenal Aneurysm Repair
  • Exclusion Criteria:
  • 1. Immunocompromised patients
  • 2. Patients with active infection
  • 3. Reoperation on the aorta
  • 4. Inflammatory bowel Disease
  • 5. Malignancy
  • 6. Chronic Inflammatory conditions (e.g. Rheymatoid arthritis, Psoriatic arthritis)
  • 7. Chronic corticosteroid or immunosuppressive drug use
  • 8. Intraoperative transfusion with \>2 units of packed Red Blood Cells

About University Of Crete

The University of Crete is a prominent academic institution dedicated to advancing medical research and education. With a strong emphasis on interdisciplinary collaboration, the university conducts innovative clinical trials aimed at addressing critical health challenges. Its research initiatives are bolstered by a team of experienced faculty and researchers, who are committed to translating scientific discoveries into effective healthcare solutions. The University of Crete's state-of-the-art facilities and commitment to ethical standards ensure that clinical trials are conducted with the highest level of integrity and rigor, contributing to the global body of medical knowledge and improving patient outcomes.

Locations

Heraklion, Crete, Greece

Patients applied

0 patients applied

Trial Officials

Vasileia Nyktari, MD,PhD

Study Chair

University of Crete, Medical School

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

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