Eosinophils in Human Adipose Tissue

Launched by MAYO CLINIC · May 18, 2021

Keywords

ClinConnect Summary

No description provided

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Obesity (BMI\>30 kg/m2).
• • Evidence of insulin resistance as defined by hemoglobin A1c \> 5.7%.
• • Mayo Clinic patients evaluated by Dr. Rahul Pannala.
• • Pursue an endoscopic gastroplasty at Mayo Clinic Arizona in the Gastroenterology department.
• • Equal distribution of gender.
• • 18 yo older of age.
• • BMI\>30 kg/m2.
• • Nonsmoker.
• • Taking no medication affecting glucose or lipid metabolism.
• • No more than 5% change in body weight in the previous 6 months.
• • Mostly sedentary (engaging in strenuous exercise (\> 70% max HR) less than 3 times a week).
• • Not be receiving corticosteroid therapy.
• • Have no history of asthma, COPD or atopic syndrome, or autoimmune disease (Ulcerative colitis, Chron's disease, eosinophilic esophagitis, any rheumatologic disease such as lupus, rheumatoid arthritis, Sjogren syndrome).
• Exclusion Criteria:
• • \<17 years of age.
• • BMI \<30 kg/m2.
• • Smoker.
• • Taking medication affecting glucose or lipid metabolism.
• • Greater than 5% change in body weight within the previous six months.
• • Engage in strenuous exercise (\>70% max HR) less than 3 times a week.
• • Receiving corticosteroid therapy.
• • Have a history of asthma.
• • History of COPD or atopic syndrome.
• • History of autoimmune disease (Ulcerative colitis, Chron's disease, eosinophilic esophagitis, any rheumatologic disease such as lupus, rheumatoid arthritis, Sjogren syndrome).