POWER Myocardial Fatigue Study: a Biomechanical Assessment of Contractility of Human Myocardium

Launched by UNIVERSITY HOSPITALS COVENTRY AND WARWICKSHIRE NHS TRUST · May 18, 2021

Keywords

ClinConnect Summary

The POWER Myocardial Fatigue Study is a research trial aimed at understanding how the human heart behaves under different conditions, especially in patients with heart failure. The study focuses on a concept called "myocardial fatigue," which refers to how well the heart can contract and pump blood. Researchers will look at how factors like heart pressure and certain medications affect heart function using samples collected during open-heart surgery.

To participate in this study, you need to be an adult between 18 and 85 years old who is undergoing open-heart surgery and can provide consent. The study also includes healthy donor hearts that cannot be used for transplants. Participants can expect to contribute to important research that could improve heart treatments in the future. It's important to note that the study is currently recruiting patients, and the researchers are taking precautions to ensure safety, such as excluding those with certain infections.

Gender

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Eligibility criteria

• Inclusion Criteria:
• • All adult patients between 18 to 85-years old undergoing open-heart surgery who can undergo the consent process for the study
• • Healthy donor hearts that are deemed non-transplantable and consent received from a legal representative
• Exclusion Criteria:
• • This criterion is kept to a minimum since the availability of human myocardial samples is finite and dependent on the limited number of patients undergoing cardiac surgery annually within the local hospital.
• • Patients who do not have the mental capacity to undergo the consent process
• • For the safety of researchers, patients with evidence of ongoing blood-borne infections such as HIV, or a recent positive test for COVID-19 (within 10 days of last PCR test).