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Search / Trial NCT04900935

Patient-centered, Optimal Integration of Survivorship and Palliative Care

Launched by MASSACHUSETTS GENERAL HOSPITAL · May 20, 2021

Trial Information

Current as of June 26, 2025

Recruiting

Keywords

Stage Iv Non Small Cell Lung Cancer Targeted Therapy Nonsmall Cell Lung Cancer Carcinoma, Non Small Cell Lung Alk Positive Non Small Cell Lung Cancer Egfr Positive Non Small Cell Lung Cancer Ros1 Positive Non Small Cell Lung Cancer Palliative Care Survivorship Ret Fusion Positive Non Small Cell Lung Cancer

ClinConnect Summary

This clinical trial is studying a new supportive care program called POISE for patients with advanced Non-small Cell Lung Cancer (NSCLC). The main goal is to see if this program can help patients feel less anxious about their future, boost their confidence in managing their cancer, and improve their understanding of what to expect as they go through treatment. Participants will either receive the POISE program, which includes four visits with a trained specialist in palliative care, or continue with standard care. They will also complete three surveys to share their experiences.

To be eligible for this trial, participants must be at least 18 years old, be patients at the MGH Cancer Center, and have been diagnosed with metastatic NSCLC with specific genetic changes (like EGFR or ALK mutations) within the last six months. They also need to be receiving targeted therapy and should be able to communicate in English or Spanish. However, those with serious mental health issues, urgent palliative needs, or who are pregnant or incarcerated cannot participate. This study is currently recruiting participants and aims to provide valuable insights into how supportive care can improve the quality of life for patients facing this challenging diagnosis.

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • Age 18 or older
  • MGH Cancer Center patient
  • Within 6 months of diagnosis of metastatic NSCLC with oncogenic driver mutation (EGFR, ALK, ROS1, RET)
  • Receiving targeted therapy
  • Ability to respond in English or Spanish
  • Exclusion Criteria:
  • Cognitive impairment or serious mental illness that limits ability to provide informed consent
  • Need for urgent palliative care or hospice referral
  • Pregnant women
  • Prisoners

About Massachusetts General Hospital

Massachusetts General Hospital (MGH) is a leading academic medical center located in Boston, Massachusetts, renowned for its commitment to advancing medical research and patient care. As a prominent teaching hospital affiliated with Harvard Medical School, MGH plays a pivotal role in clinical trials across a wide range of disciplines, including cardiology, oncology, neurology, and more. The institution is dedicated to fostering innovative research that translates into effective therapies and improved health outcomes. MGH's Clinical Trials Office provides comprehensive support to facilitate the design, implementation, and management of clinical studies, ensuring adherence to the highest ethical standards and regulatory compliance. With a focus on collaboration and patient-centered care, MGH strives to enhance medical knowledge and contribute to the future of healthcare.

Locations

Boston, Massachusetts, United States

Boston, Massachusetts, United States

Patients applied

0 patients applied

Trial Officials

Laura A Petrillo, MD

Principal Investigator

Massachusetts General Hospital

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

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