OTSC vs. Angiographic Embolization in Patients With Refractory Non-variceal Upper Gastrointestinal Bleeding

Launched by CHINESE UNIVERSITY OF HONG KONG · May 25, 2021

Keywords

ClinConnect Summary

This clinical trial is studying two different methods for treating patients who have serious bleeding in the upper part of the digestive system, specifically when traditional treatments are not effective. The two methods being compared are OTSC, which is a technique that involves placing a special clip to stop the bleeding, and angiographic embolization (TAE), a procedure that blocks the blood vessels causing the bleeding. The goal is to find out if using OTSC first can provide similar results to TAE, potentially allowing for a quicker and less invasive treatment.

To participate in this trial, patients should be adults aged 65 and older who show clear signs of bleeding, such as vomiting blood or having dark, tarry stools. They should have a documented bleeding problem identified during an endoscopy, which is a procedure that allows doctors to see inside the stomach and digestive tract. Participants can expect to undergo either of the two treatments and be monitored for their recovery. It's important to note that this study is currently recruiting, and interested patients will need to provide their consent or have a family member do so if they are unable.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Patients presented with overt signs of acute upper gastrointestinal bleeding (hematemesis, melena and/or hypotension) 2. documented bleeding lesion at endoscopy (ulcer, dieulafoy's lesion and others), further bleeds (persistent or recurrent) after endoscopic hemostasis (thermal or hemoclips) as defined by an International Consensus Group
• Exclusion Criteria:
• • 1. without a full informed consent from the patient or his next of kin
• • 2. Age \<18 years
• • 3. Pregnant
• • 4. Lactating women
• • 5. patients with known allergy to intravenous contrast