External Nitric Oxide Measurement Through SNO Degradation

Launched by INDIANA UNIVERSITY · May 25, 2021

Keywords

ClinConnect Summary

This early, small study is testing a new, noninvasive way to measure nitric oxide (a gas involved in body signaling) using a 365 nm UV flashlight on the ear. It’s being done in healthy volunteers to see if this method can reliably detect NO changes, which could one day help with simpler testing in the future. About 150 people from ages 1 day up to 75 years may enroll. Participants must not be smokers, must not have ongoing skin conditions, and must be willing and able to participate. The study is being conducted at two Indianapolis sites and is led by Indiana University.

What to expect if you participate: there will be a baseline NO test on the ear, then three short, low‑intensity UV exposures to the ear while NO is measured with a connected device. After the exposures, researchers will collect small air samples from the ear 15 minutes later. Everyone wears UV safety goggles during the procedure. This is a research, device‑based, single‑group study with no treatment involved, and results aren’t available yet. The study is still enrolling by invitation, with completion expected in late 2025.

Gender

ALL

Eligibility criteria

• • Inclusion Criteria
• • Adult males or females age ≥ 1 day and ≤ 75 years at time of enrollment
• • Exclusion Criteria
• * Subjects meeting the following criteria will be excluded:
• • Smokers.
• • Any chronic skin conditions.
• • Pregnant.
• • Subjects that are unable or unwilling to cooperate with specimen collection.
• • Subjects with diagnosis of any medical condition that in the investigator's opinion would make them unsuitable for study participation.
• • (for subjects ≥ 18) Subjects that lack the capacity to consent for themselves.