A Study to Evaluate Safety, Efficacy, and Pharmacokinetics in Participants With Advanced Solid Tumors

Launched by EUTILEX · May 25, 2021

Keywords

ClinConnect Summary

This clinical trial is studying a new treatment called EU101 for patients with advanced solid tumors, including renal cell cancer, non-small cell lung cancer, and prostate cancer. The trial has two phases: the first phase focuses on understanding the safety and appropriate dosage of EU101, while the second phase will look at how effective it is specifically for colorectal and non-small cell lung cancers. The trial is currently recruiting participants, and those who might be eligible include individuals whose cancer has either not responded to standard treatments or for whom no standard treatment is available.

To participate, patients should have a confirmed diagnosis of advanced solid tumors and meet certain health criteria, such as having a life expectancy of at least 12 weeks and adequate organ function. Participants will need to provide consent to join the study and may be required to use effective birth control methods during the trial. Throughout the study, participants will be closely monitored for any side effects and the overall effectiveness of the new treatment. This trial could potentially offer new hope for patients with hard-to-treat cancers.

Gender

ALL

Eligibility criteria

• Key Inclusion Criteria:
• • Histologically or cytologically confirmed diagnosis of metastatic or locally advanced solid tumors for which no standard therapy exists or standard therapy has failed because of disease progression or unacceptable toxicities. Also includes patients who cannot be treated with standard therapy because of underlying/existing medical condition.
• • Cohort 1 (colorectal cancer): a) CRC (including microsatellite instability-high \[MSI-H\] and microsatellite-stable \[MSS\]) regardless of RAS mutation. b) Disease progression within 3 months after last administration of approved standard therapies. c) Prior cytotoxic chemotherapy for metastatic disease include all the following agents: fluoropyrimidine, oxaliplatin, and irinotecan
• • Adjuvant chemotherapy-based treatments count as prior therapy, as long as relapse had occurred within 6 months of completion of such therapies, prior anti-epidermal growth factor receptor (EGFR) therapy (cetuximab, panitumumab), anti-angiogenic therapy (bevacizumab, aflibercept, ramucirumab), regorafenib, and TAS-102 are allowed. d) No more than 5 prior therapies for metastatic disease. For participants who had disease recurrence within 6 months of completing adjuvant chemotherapy, the adjuvant regimen can be considered as 1 chemotherapy regimen for metastatic disease
• • Cohort 2 (NSCLC): a) NSCLC without known EGFR, anaplastic lymphoma kinase (ALK), and ROS1 genomic tumor aberrations. b) No standard therapy exists or standard therapy has failed. c) No more than 3 prior therapies for metastatic disease
• • Phase 2: At least 1 measurable lesion per RECIST version 1.1
• • Eastern Cooperative Oncology Group (ECOG) performance score of 0 to 2
• • Adequate organ and bone marrow function (Hemoglobin \>9.0 g/dL, Absolute neutrophil count ≥1,500/μL, Absolute lymphocyte count ≥600 and ≤2,500/μL, Platelet count ≥100,000/μL, Total bilirubin ≤1.5 × upper limit of normal, Alanine aminotransferase and aspartate aminotransferase ≤2.5 × ULN, Serum creatinine ≤1.5 × ULN or creatinine clearance \>30 mL/min, Prothrombin time and activated partial thromboplastin time ≤1.5 × ULN)
• • Life expectancy of at least 12 weeks
• • Voluntarily provided a written consent to participate in the study
• • Women of childbearing potential (WOCBP) must have a negative serum pregnancy test within the 7 days before study drug administration
• • WOCBP and sexually active fertile male patients with partners who are WOCBP must agree to use 2 highly effective methods of contraception throughout the course of the study and for 12 weeks after the last dose of study drug.
• Key Exclusion Criteria:
• • Primary central nervous system (CNS) tumor (Phase 1), CNS metastasis, and/or carcinomatous meningitis. Participants with prior brain metastases treated at least 4 weeks before the first dose of EU101 that are clinically stable and do not require chronic corticosteroid treatment are allowed. Untreated but asymptomatic and clinically stable brain metastases per investigator's discretion are allowed
• • Received prior therapy with any anti-CD137 monoclonal antibody (mAb) or agent
• • Major surgery requiring general anesthesia within 3 weeks before first dose of EU101 or still recovering from prior surgery
• • Active infection that is not controlled or requires intravenous antibiotics in the last 2 weeks
• • History of allogeneic tissue or organ transplant
• • Active hepatitis B virus or hepatitis C virus infection
• • History of any noninfectious hepatitis
• • Human immunodeficiency virus (HIV) infection
• • Received or receiving systemic corticosteroid therapy or any other form of systemic immunosuppressive medicaion 1 week before first dose of EU101
• • Known severe (≥Grade 3) hypersensitivity reactions to antibody, or severe reaction to immuno-oncology agents requiring treatment with steroids
• • Konwn or suspected hypersensitivity to EU101 or any component of its formulation
• • Current or history of interstitial lung disease, anaphylaxis, uncontrolled asthma, or pneumonitis that has required systemic corticosteroids
• • Patients with second primary cancer
• • Clinically significant concurrent cardiovascular disease
• • Pregnant women, breasfeeding women, WOCBP, or men with partners who are WOCBP who do not agree to use adequate contraceptive measures
• • Determined as unable to participate in the study per investigator's judgment
• • Other protocol defined Inclusion/Exclusion criteria may apply