Feasibility of Use of Indocyanine Green in Pediatric Colorectal Surgery

Launched by LONDON HEALTH SCIENCES CENTRE RESEARCH INSTITUTE OR LAWSON RESEARCH INSTITUTE OF ST. JOSEPH'S · May 21, 2021

Keywords

ClinConnect Summary

This clinical trial is studying the use of a special dye called Indocyanine Green (ICG) during surgeries for children with Hirschsprung's Disease and anorectal malformations. These conditions affect how the colon and rectum work, often requiring surgery to fix them. One of the risks of these surgeries is that the bowel can narrow or develop leaks where it is reconnected. ICG helps doctors see which parts of the bowel have good blood flow by lighting up green under special cameras. The hope is that this will help reduce the chances of complications during surgery, improving the overall recovery for young patients.

To participate in this study, children aged between one month and seven years who have been diagnosed with either Hirschsprung's Disease or anorectal malformations and require surgery may be eligible. Parents or guardians will need to understand and agree to the study. If a child joins the trial, doctors will collect information on how well they can recruit participants, as well as data on any complications, hospital stay, and follow-up care. The trial is currently recruiting participants, aiming to gather enough information to potentially expand the study in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• 1. All patients with Hirschsprung's disease or anorectal malformations, diagnosed by:
• • 1. Clinical evaluation and physical examination
• • 2. Radiologic studies including abdominal x-rays and/or contrast enemas
• • 3. Pathologic diagnosis after rectal biopsies (HD only)
• • 2. Patients greater than one-month of age to 7 years of age at the time of surgery
• • 3. Patient requires surgical management for their diagnosis
• • 4. Patient/Substitute decision maker (SDM) able to read/write/understand English
• Exclusion Criteria:
• • 1. Those patients and SDM unwilling to provide consent
• • 2. Pregnant and/or women who are breast feeding
• • 3. Patients with a known iodine allergy