PEEP in Patients With Acute Respiratory Failure

Launched by JESUS VILLAR · May 31, 2021

Keywords

ClinConnect Summary

This clinical trial is studying the use of a technique called Positive End-Expiratory Pressure (PEEP) in patients suffering from acute respiratory failure, which is a serious condition where the lungs cannot provide enough oxygen to the body. The trial aims to find the best level of PEEP that helps improve lung function and oxygen delivery in patients who are on a ventilator. Researchers want to see if the findings from earlier studies about PEEP are still valid with today's treatment methods, which use lower amounts of air during breathing support.

To participate in this study, individuals must be at least 18 years old, be on a ventilator for more than 24 hours, and have acute hypoxemic respiratory failure, meaning they have low oxygen levels in the blood due to lung issues. However, patients with certain conditions, like severe head or chest injuries, or those who cannot lie flat, will not be eligible. If someone qualifies and chooses to take part, they can expect to be closely monitored as researchers adjust the PEEP levels to determine what works best for their breathing support. This study is currently recruiting participants of all genders and aims to improve care for patients with respiratory failure.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Intubated patients requiring MV for \>24 h
• • Age \>18 years
• • Acute hypoxemic respiratory failure, defined as a PaO2/FiO2 \<300 with an FiO2 ≥0.3 and PEEP≥5 cmH2O.
• • ARF caused by pulmonary insults.
• Exclusion Criteria:
• • ARF from non-pulmonary origin.
• • Contraindications from high PEEP (severe head trauma or severe chest trauma).
• • Patients that cannot maintained supine position.
• • Uncorrected hypovolemia
• • Hemodynamic instability