Effects of a Classic High-frequency rTMS Treatment Versus a Deep rTMS Treatment

Launched by CENTRE HOSPITALIER HENRI LABORIT · Jun 29, 2021

Keywords

ClinConnect Summary

This clinical trial is investigating two types of brain stimulation treatments for adults aged 18 and older who are struggling with depression that hasn’t improved with standard medications. The goal is to see if a newer treatment called deep rTMS, which uses a helmet-shaped device to reach deeper parts of the brain, is more effective than the classic high-frequency rTMS treatment, which uses a different device shaped like an 8.

Participants in the study will receive either the classic rTMS treatment or the deep rTMS treatment, along with their usual therapy, over a total of 20 sessions, scheduled five times a week. They will also have three follow-up visits at 30, 60, and 90 days after starting treatment. To be eligible, individuals must be at least 18 years old, have a specific type of depression, and be on stable antidepressant medication for at least three weeks. However, some people may not qualify if they have certain severe mental health conditions, a history of seizures, or other medical issues that could complicate the treatment. This trial is currently recruiting participants, and it aims to provide hope for those who have not found relief from traditional depression treatments.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Volunteer subjects over 18 years old
• • Having signed a free and informed consent
• • Having a diagnostic of caracterised depressive episod recurrent or isolated according to DSM IV criteria (A.P.A 1994).
• • Having an antidepressant treatment not modified since 3 weeks
• • Score to MADRS scale ≥ 21
• • Subject affiliated to a social security regimen
• Exclusion Criteria:
• • Depression with psychotic caracteristics
• • Co-morbid diagnosis according to axis I (DSM IV) of schizophrenia, dependence (or abuse) on alcohol and / or another substance (lifetime)
• • Patient who has already undergone seismotherapy for current episode and non-responder to this treatment
• • Patient hospitalized under duress or under legal protection (guardianship, curatorship)
• • Patient with a high risk of suicide (item 10 of MADRS \> 4) in the absence of hospitalization.
• • Contra-indication for IRM exam or rTMS : personnal history of comitial crisis, of neurological or neurochirurgical pathologies, metallic prosthetic material or foreign body (pacemaker, intraoculare ferromagnetic material, implanted cardiac defibrillator, cochlear implant, metal clip
• • Pregnancy
• • Simultaneous participation to another interventionnal study