Effect of Benzalkonium Chloride Preserved and Preservative-free Latanoprost Eye Drops on Conjunctival Goblet Cells

Launched by RIGSHOSPITALET, DENMARK · Jun 30, 2021

Keywords

ClinConnect Summary

This clinical trial is studying how two types of eye drops—one with a preservative called benzalkonium chloride and one without preservatives—affect special cells in the eye called conjunctival goblet cells. These cells help keep the surface of the eye moist and healthy, which is especially important for people with conditions like glaucoma and ocular hypertension. The study is currently looking for participants aged 18 and older who speak Danish and have open-angle glaucoma or ocular hypertension, with an average eye pressure of 22 mmHg or higher.

If you decide to participate, you'll be randomly assigned to use either the preserved or preservative-free eye drops for a certain period. Throughout the study, your eye health will be monitored to see how each type of drop affects the goblet cells. It's important to note that certain conditions, like recent eye injuries, serious health issues, or being pregnant, may prevent someone from participating. This trial aims to find out which type of eye drop is better for maintaining eye health in patients with glaucoma or ocular hypertension.

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Eligibility criteria

• Inclusion Criteria:
• • 1. Age \>18years
• • 2. Danish speaking
• • 3. Open angle glaucoma or ocular hypertension
• • 4. Average intraocular pressure equal to or above 22 mmHg
• Exclusion Criteria:
• • a. history of significant eye diseae (including okular trauma) other than open angle glaucoma and ocular hypertension d. treatment with steroids within the last 3 months from inclusion e. Significant untreated systemic disease such as hypertension, heart failure, diabetes mellitus, stroke, lung disease and autoimmune diseases. Diseases are not reason for exclusion if they are well treated or does not need treatment g. pregnant or breast feeding h. women using unsafe anticonception i. allergy towards trial medication j. patients who cannot cooperate in eye examination k. ocular surface defects l. need for polytherapy in glaucoma treatment