LIMIT Early Adiposity Rebound in Children

Launched by UNIVERSITY OF PAVIA · Jul 1, 2021

Keywords

ClinConnect Summary

The LIMIT trial is studying how a child’s gut health and their mother’s lifestyle choices during pregnancy and early life can affect the risk of childhood obesity. Researchers want to understand the connection between the gut microbiome—tiny organisms living in the digestive system—and factors like diet, environmental influences, and growth patterns in children. They are particularly interested in how early weight gain (called early adiposity rebound) can predict future obesity, which can lead to health problems later in life.

To participate in this study, families need to have an infant aged between birth and 4 years. Eligible parents must be able to speak Italian and give consent for their child to be part of the research. The study will involve around 150 mother-infant pairs and will follow them over the first four years of the child’s life. Parents can expect to complete questionnaires and provide information about their lifestyle, diet, and other factors that may influence their child’s health. This trial aims to gather important information that could help predict early obesity and improve health outcomes for children.

Gender

ALL

Eligibility criteria

• • Inclusion criteria: i) Infants of both sexes born to vaginal/caesarean delivery; ii) Gestational age: 37-42 weeks; iii) Italian-speaking parent; iv) 7 Ability of the parent/guardian to give informed consent; v) Ability of the mother to answer questionnaires.
• • Exclusion Criteria: i) Infants with genetic/congenital diseases; ii) Infants selected for another clinical study; iii) Infants hospitalized immediately after birth; iv) Presence of gestational diabetes; v) Presence of hyperthyroidism during pregnancy; vi) Parents refusing to sign the informed consent.