Impact of Dyspnea, Regional Lung Ventilation, and Diaphragmatic Function During de Novo Acute Respiratory Failure

Launched by ASSISTANCE PUBLIQUE - HÔPITAUX DE PARIS · Jul 5, 2021

Keywords

ClinConnect Summary

This clinical trial is studying how to better manage acute respiratory failure, which is a serious condition where the lungs cannot get enough oxygen to the body. The trial aims to understand how patients feel short of breath (dyspnea), how well their lungs are working in different areas, and how their diaphragm (a muscle that helps us breathe) is functioning. By observing these factors, researchers hope to identify who is at risk of needing a breathing tube (intubation) and to improve treatments that help patients breathe without invasive methods.

To participate in this study, individuals must be over 18 years old and show signs of acute respiratory insufficiency, such as low oxygen levels and a fast breathing rate, while needing significant oxygen support. Patients who have certain chronic lung diseases, severe respiratory issues, or other specific health concerns may not be eligible. Those who join the trial can expect to undergo various assessments to monitor their breathing and lung function, helping doctors understand the best ways to support patients experiencing acute respiratory failure.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age \> 18
• * Acute respiratory insufficiency defined by the three following items :
• • 1. PaO2/ FiO2 \<300
• • 2. Respiratory rate \> 25/min
• • 3. Oxygen support \> 10L/min or High Flow nasal oxygen (HFNO)
• • Non opposition by the patient to be included
• • Social insurance
• Exclusion Criteria:
• • Respiratory acidosis (pH \< 7,35 PaCO2 \> 45mmHg or 6kPa)
• • Chronic respiratory disease ( COPD, bronchiectasis...)
• • Cardiogenic Acute lung oedema
• • Non intubation decision at randomisation
• • Contraindication for Electro-impedance tomography-belt placement (chest trauma with rib fractures, thoracic wound, chest tube).
• • Uncommunicative patient (Glasgow coma scale \<12)
• • Guardianship or curators for vulnerable patients.