A Study Evaluating the Efficacy and Safety of Adjuvant Giredestrant Compared With Physician's Choice of Adjuvant Endocrine Monotherapy in Participants With Estrogen Receptor-Positive, HER2-Negative Early Breast Cancer (lidERA Breast Cancer)
Launched by HOFFMANN-LA ROCHE · Jul 5, 2021
Trial Information
Current as of June 27, 2025
Recruiting
Keywords
ClinConnect Summary
This clinical trial, called the lidERA Breast Cancer study, is looking at a new treatment called giredestrant for patients with early breast cancer that is positive for estrogen receptors and negative for HER2. The main goal is to see if giredestrant is more effective and safer compared to the standard hormone therapy chosen by the patient's doctor. This study is open to adults aged 65 to 74 who have had surgery for their breast cancer and meet certain health criteria, such as having the right type of tumor and being able to take oral medication.
If you qualify and choose to participate, you will be randomly assigned to receive either giredestrant or your doctor's choice of hormone therapy. There is also a smaller part of the study exploring the combination of giredestrant with another medication called abemaciclib. Throughout the trial, participants will be monitored closely for any side effects and to see how well the treatment works. This trial is currently recruiting participants, and it could be an opportunity to access a potentially beneficial treatment while contributing to important research in breast cancer care.
Gender
ALL
Eligibility criteria
- Primary Study Inclusion Criteria:
- • Documented estrogen receptor (ER)-positive and HER2-negative breast tumor, as assessed locally on a primary disease specimen
- • Participants who have multicentric (the presence of two of more tumor foci within different quadrants of the same breast) and/or multifocal (the presence of two or more tumor foci within a single quadrant of the breast) breast cancer are also eligible if all examined tumors meet pathologic criteria for ER positivity and HER2 negativity
- • Participants must have undergone definitive surgery of their primary breast tumor(s) and axillary lymph nodes (axillary lymph node dissection \[ALND\] and/or sentinel lymph node biopsy \[SLNB\])
- • Participants who received or will be receiving adjuvant chemotherapy must have completed adjuvant chemotherapy prior to randomization. Participants may also have received neoadjuvant chemotherapy. A washout period of at least 21 days is required between last adjuvant chemotherapy dose and randomization.
- • Resolution of all acute toxic effects of prior anti-cancer therapy or surgical procedures to NCI CTCAE v5.0 Grade 1 or better (except alopecia, Grade ≤2 peripheral neuropathy, arthralgia or other toxicities not considered a safety risk for the participant per the investigator's judgment)
- • Participants have received (neo)adjuvant chemotherapy and/or had surgery and had no prior endocrine therapy are eligible, provided that they are enrolled within 12 months following definitive breast cancer surgery
- • Participants who have confirmed availability of an untreated primary breast tumor tissue specimen suitable for biomarker testing (i.e., representative archived formalin-fixed, paraffin-embedded \[FFPE\] tissue block \[preferred\] or 15-20 slides containing unstained, freshly cut, serial sections), with associated de-identified pathology report is required. Although 15-20 slides are preferred, if only 10-14 slides are available, the individual may still be eligible for the study.
- • Participants with node-positive and node-negative disease are eligible provided they meet additional risk criteria as defined in the protocol
- • Eastern Cooperative Oncology Group (ECOG) Performance Status 0, 1, or 2
- • Able and willing to swallow, retain, and absorb oral medication
- • Adequate organ function
- Substudy Inclusion Criteria:
- To be eligible for substudy participation, in addition to meeting the inclusion criteria in the primary protocol, participants must also meet the following modified criteria:
- • - Patients who received adjuvant radiotherapy must have completed radiotherapy prior to enrollment, and patients must have recovered (to Grade ≤1) from the acute effects of radiotherapy. A washout period of at least 14 days is required between end of radiotherapy and enrollment.
- Primary Study Exclusion Criteria:
- • Pregnant or breastfeeding, or intending to become pregnant during the study or within 10 days after the final dose of giredestrant, or within the time period specified per local prescribing guidelines after the final dose of the endocrine therapy of physician's choice
- • Received treatment with investigational therapy within 28 days prior to initiation of study treatment or is currently enrolled in any other type of medical research judged by the sponsor not to be scientifically or medically compatible with this study
- • Receiving or planning to receive a CDK4/6 inhibitor as (neo)adjuvant therapy. A short course of up to 12 weeks of neoadjuvant or adjuvant treatment with CDK4/6 inhibitor therapy prior to randomization is allowed.
- • Active cardiac disease or history of cardiac dysfunction
- • Diagnosed with Stage IV breast cancer
- • A history of any prior (ipsilateral and/or contralateral) invasive breast cancer or ductal carcinoma in situ (DCIS). Participants with a history of contralateral DCIS treated by only local regional therapy at any time may be eligible.
- • A history of any other malignancy within 3 years prior to screening, except for appropriately treated carcinoma in situ of the cervix, nonmelanoma skin carcinoma, or Stage I uterine cancer
- • Any prior endocrine treatment with selective ER modulators (e.g., tamoxifen), degraders, or aromatase inhibitors. A short course of neoadjuvant or adjuvant endocrine therapy (up to 12 weeks) is allowed.
- • Clinically significant liver disease consistent with Child-Pugh Class B or C, including active hepatitis (e.g., hepatitis B virus \[HBV\] or hepatitis C virus \[HCV\]), current alcohol abuse, cirrhosis, or positive test for viral hepatitis
- • Treatment with strong CYP3A4 inhibitors or inducers within 14 days or 5 drug elimination half-lives (whichever is longer) prior to initiation of study treatment
- • Known allergy or hypersensitivity to any of the study drugs or any of their excipients
- • Pre- and perimenopausal participants or male participants who have a known hypersensitivity to LHRH agonists
- • A documented history of hemorrhagic diathesis, coagulopathy, or thromboembolism
- • Renal dysfunction that requires dialysis
- • A major surgical procedure unrelated to breast cancer within 28 days prior to randomization
- • A serious infection requiring oral or IV antibiotics within 14 days prior to screening or other clinically significant infection (e.g., COVID-19) within 14 days prior to screening
- • Any serious medical condition or abnormality in clinical laboratory tests that, in the investigator's judgment, precludes an individual's safe participation in and completion of the study
- • Unable or unwilling to comply with the requirements of the protocol in the opinion of the investigator
- Substudy Exclusion Criteria:
- Potential participants are excluded from the substudy if any criteria from t\\he primary study or the following criteria apply:
- • Prior participation in the GO42784 primary study
- • Received a CDK4/6i as (neo)adjuvant therapy prior to enrollment
- • Treatment with moderate CYP3A inducers, strong CYP3A inducers or strong CYP3A inhibitors within 14 days or 5 drug elimination half-lives (whichever is longer) prior to initiation of study treatment
About Hoffmann La Roche
Hoffmann-La Roche, commonly known as Roche, is a global leader in biotechnology and pharmaceuticals, committed to advancing healthcare through innovative research and development. With a strong focus on oncology, immunology, infectious diseases, and central nervous system disorders, Roche leverages cutting-edge science to deliver transformative therapies and diagnostics. The company is dedicated to improving patient outcomes by conducting rigorous clinical trials and collaborating with healthcare professionals and organizations worldwide. Roche's unwavering commitment to precision medicine and personalized healthcare positions it at the forefront of the industry, driving progress in the quest for effective treatments and improved patient care.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Ann Arbor, Michigan, United States
Lexington, Kentucky, United States
Madison, Wisconsin, United States
Iowa City, Iowa, United States
Buffalo, New York, United States
Rouen, , France
Detroit, Michigan, United States
Saint Louis, Missouri, United States
Sioux Falls, South Dakota, United States
Avignon, , France
Lille, , France
Adelaide, South Australia, Australia
Seattle, Washington, United States
Edmonton, Alberta, Canada
Regina, Saskatchewan, Canada
Long Beach, California, United States
Chicago, Illinois, United States
Liverpool, New South Wales, Australia
Lima, , Peru
Kingman, Kansas, United States
Madrid, , Spain
Preston, , United Kingdom
Valencia, , Spain
Barcelona, , Spain
Miami Beach, Florida, United States
Madrid, , Spain
Zaragoza, , Spain
Moncton, New Brunswick, Canada
Sherbrooke, Quebec, Canada
Hong Kong, , Hong Kong
Malaga, , Spain
Cork, , Ireland
Dublin, , Ireland
Galway, , Ireland
Auchenflower, Queensland, Australia
Box Hill, Victoria, Australia
Frankston, Victoria, Australia
Chur, , Switzerland
Barcelona, , Spain
Murcia, , Spain
Milwaukee, Wisconsin, United States
Cleveland, Ohio, United States
Oxford, , United Kingdom
Madison, Wisconsin, United States
Orlando, Florida, United States
Mineola, New York, United States
Valencia, , Spain
Bangkok, , Thailand
Gent, , Belgium
Brighton, , United Kingdom
Nottingham, , United Kingdom
Nedlands, Western Australia, Australia
Colton, California, United States
Cedar Rapids, Iowa, United States
Bangkok, , Thailand
Barcelona, , Spain
Norfolk, Virginia, United States
Gainesville, Florida, United States
Winston Salem, North Carolina, United States
Kampala, , Uganda
Madrid, , Spain
Los Angeles, California, United States
Woolloongabba, Queensland, Australia
Bedford Park, South Australia, Australia
Taipei, , Taiwan
New Orleans, Louisiana, United States
West Reading, Pennsylvania, United States
Ringwood East, Victoria, Australia
Jau, Sp, Brazil
Shanghai City, , China
Olomouc, , Czechia
Palo Alto, California, United States
Porto Alegre, Rs, Brazil
Liege, , Belgium
Caen, , France
Uppsala, , Sweden
Frankston, Victoria, Australia
Alicante, , Spain
Villejuif, , France
Townsville, Queensland, Australia
Kuala Lumpur, , Malaysia
Hiroshima, , Japan
Warrnambool, Victoria, Australia
Bankstown, New South Wales, Australia
Barcelona, , Spain
Cadiz, , Spain
Elche, Alicante, Spain
Pamplona, Navarra, Spain
Sevilla, , Spain
Granada, , Spain
Murcia, , Spain
Vallejo, California, United States
Essen, , Germany
Fukushima, , Japan
Paris, , France
Eindhoven, , Netherlands
Madrid, , Spain
Taipei, , Taiwan
Kuala Lumpur, , Malaysia
Bruxelles, , Belgium
Heidelberg, , Germany
Leicester, , United Kingdom
Paris, , France
Limoges, , France
St. Gallen, , Switzerland
Canton, Ohio, United States
Campbelltown, New South Wales, Australia
Chicago, Illinois, United States
Taichung, , Taiwan
Venlo, , Netherlands
Los Angeles, California, United States
Tübingen, , Germany
Jönköping, , Sweden
Granada, , Spain
Burlington, Massachusetts, United States
Hong Kong, , Hong Kong
Innsbruck, , Austria
Vellore, Tamil Nadu, India
Wels, , Austria
Joliet, Illinois, United States
Leuven, , Belgium
Basel, , Switzerland
Osaka, , Japan
Pittsburgh, Pennsylvania, United States
Kumamoto, , Japan
Raleigh, North Carolina, United States
Beijing, , China
Praha 2, , Czechia
Edegem, , Belgium
Saitama, , Japan
Seongnam Si, , Korea, Republic Of
Paris, , France
Seoul, , Korea, Republic Of
Las Vegas, Nevada, United States
Kuching, Sarawak, Malaysia
Bratislava, , Slovakia
Bangkok, , Thailand
Taipei, , Taiwan
Madrid, , Spain
Richmond, Virginia, United States
Valencia, , Spain
Sundsvall, , Sweden
Paris, , France
Chai Wan, , Hong Kong
Barcelona, , Spain
San Miguel De Tucuman, , Argentina
Sabadell, Barcelona, Spain
Salvador, Bahia, Ba, Brazil
Porto Alegre, Rs, Brazil
Ljubljana, , Slovenia
Providence, Rhode Island, United States
Paris, , France
Johannesburg, , South Africa
Lubbock, Texas, United States
Plainfield, Illinois, United States
Ijui, Rs, Brazil
Penang, , Malaysia
Guangzhou, Guangdong, China
Seongnam Si, , Korea, Republic Of
Varazdin, , Croatia
Itajai, Sc, Brazil
Jau, Sp, Brazil
Bangkok, , Thailand
Baguio City, , Philippines
Epping, Victoria, Australia
Nis, , Serbia
Shepparton, Victoria, Australia
Santa Monica, California, United States
Billings, Montana, United States
Cincinnati, Ohio, United States
Rio De Janeiro, Rj, Brazil
Sao Paulo, Sp, Brazil
Sorocaba, Sp, Brazil
Ivanovo, , Russian Federation
Kanagawa, , Japan
Pula, , Croatia
Olomouc, , Czechia
Changchun, Jilin, China
Santa Barbara, California, United States
Chengdu, , China
Lima, , Peru
Caceres, , Spain
Budapest, , Hungary
Belgrade, , Serbia
New Brunswick, New Jersey, United States
Charlotte, North Carolina, United States
Praha 5, , Czechia
Pittsburgh, Pennsylvania, United States
Cleveland, Ohio, United States
Kurralta Park, South Australia, Australia
Kragujevac, , Serbia
Hong Kong, , Hong Kong
Montreal, Quebec, Canada
Miskolc, , Hungary
Erlangen, , Germany
Leicester, , United Kingdom
Reggio Emilia, Emilia Romagna, Italy
Palma De Mallorca, Islas Baleares, Spain
Asheville, North Carolina, United States
Cairns, Queensland, Australia
Budapest, , Hungary
Jacksonville, Florida, United States
The Woodlands, Texas, United States
Harbin, , China
Incheon, , Korea, Republic Of
Oaxaca, , Mexico
Taoyuan, , Taiwan
Grenoble, , France
Stamford, Connecticut, United States
London, , United Kingdom
Dalian, , China
Port Elizabeth, , South Africa
Port Macquarie, New South Wales, Australia
Pisa, , Italy
La Rioja, , Argentina
Chemnitz, , Germany
Athens, , Greece
Budapest, , Hungary
Budapest, , Hungary
Taipei, , Taiwan
Mannheim, , Germany
Mainz, , Germany
Hokkaido, , Japan
Tokyo, , Japan
Baden, , Switzerland
Chengdu, Sichuan, China
Split, , Croatia
Alcorcon, Madrid, Spain
Calgary, Alberta, Canada
Mainz, , Germany
Seongnam, , Korea, Republic Of
Praha, , Czechia
Lima, , Peru
Taipei City, , Taiwan
Seoul, , Korea, Republic Of
Lima, , Peru
Maastricht, , Netherlands
Mostar, , Bosnia And Herzegovina
Shenyang, , China
Incheon, , Korea, Republic Of
Ulsan, , Korea, Republic Of
Cluj Napoca, , Romania
Pinehurst, North Carolina, United States
Jaen, , Spain
Changsha, Hunan, China
Edirne, , Turkey
Bilbao, Vizcaya, Spain
Iloilo City, , Philippines
Seoul, , Korea, Republic Of
Zhengzhou, Henan, China
Nagpur, Maharashtra, India
Auchenflower, Queensland, Australia
Petaling Jaya, Selangor, Selangor, Malaysia
Tampere, , Finland
Manchester, , United Kingdom
Sremska Kamenica, , Serbia
Valladolid, , Spain
Reus, Tarragona, Spain
Stockholm, , Sweden
Xi'an, , China
Wien, , Austria
Helsinki, , Finland
Münster, , Germany
Timişoara, , Romania
Odesa, Kherson Governorate, Ukraine
Kurralta Park, South Australia, Australia
St Albans, Victoria, Australia
Seoul, , Korea, Republic Of
Hangzhou, Zhejiang, China
Pula, , Croatia
Seoul, , Korea, Republic Of
Lisboa, , Portugal
Omaha, Nebraska, United States
Harrisburg, Pennsylvania, United States
Porto Alegre, Rio Grande Do Sul, Brazil
Rosario, , Argentina
Hangzhou, , China
Floridablanca, , Colombia
Johannesburg, , South Africa
Las Vegas, Nevada, United States
York, Pennsylvania, United States
Cape Town, , South Africa
New Taipei City, , Taiwan
Cairns, Queensland, Australia
Avila, , Spain
Pergamino, , Argentina
San Miguel De Tucuman, , Argentina
Seville, Sevilla, Spain
S. Cristobal De La Laguna, Tenerife, Spain
Zhengzhou, , China
Jau, São Paulo, Brazil
Västerås, , Sweden
Baton Rouge, Louisiana, United States
Roseville, California, United States
Naperville, Illinois, United States
Kansas City, Missouri, United States
Morgantown, West Virginia, United States
Changchun, , China
Wuhan, , China
Monteria, , Colombia
Prato, Toscana, Italy
Seongnam Si, , Korea, Republic Of
Trujillo, , Peru
Zürich, , Switzerland
Cornwall, , United Kingdom
Iasi, , Romania
Nanning, , China
Praha, , Czechia
Kuopio, , Finland
Craiova, , Romania
Columbus, Ohio, United States
Seoul, , Korea, Republic Of
Madrid, , Spain
Bendigo, Victoria, Australia
Gera, , Germany
Richmond, Virginia, United States
Madrid, , Spain
Debrecen, , Hungary
Pasig City, , Philippines
Madrid, , Spain
Buenos Aires, , Argentina
Porto Alegre, Rs, Brazil
Temuco, , Chile
Košice, , Slovakia
Skoevde, , Sweden
Valladolid, , Spain
Lynchburg, Virginia, United States
Pisa, , Italy
Osaka, , Japan
Gyeonggi Do, , Korea, Republic Of
Santa Clara, California, United States
Tel Aviv, , Israel
Moscovskaya Oblast, Moskovskaja Oblast, Russian Federation
Kaohsiung City, , Taiwan
Santa Rosa, California, United States
Billings, Montana, United States
New York, New York, United States
North Sydney, New South Wales, Australia
Zhejiang, , China
Madrid, , Spain
Tigard, Oregon, United States
Houston, Texas, United States
Montreal, Quebec, Canada
Albury, New South Wales, Australia
Albacete, , Spain
Hamburg, , Germany
Chongqing, , China
Dakahlia, , Egypt
Pisa, Toscana, Italy
San Francisco, California, United States
El Paso, Texas, United States
Cheongju Si, , Korea, Republic Of
Seoul, , Korea, Republic Of
Seoul, , Korea, Republic Of
San Diego, California, United States
Lexington, Massachusetts, United States
Tuzla, , Bosnia And Herzegovina
Barcelona, , Spain
Majadahonda, Madrid, Spain
Kunming, , China
Xiamen, , China
San Jose, California, United States
Buenos Aires, , Argentina
Santo Andre, Sp, Brazil
Porto Alegre, Rio Grande Do Sul, Brazil
Mar Del Plata, Buenos Aires, Argentina
Zalaegerszeg, , Hungary
Montreal, Quebec, Canada
Roma, Lazio, Italy
Lisboa, , Portugal
Monterrey, , Mexico
Xuzhou, , China
Nagpur, Maharashtra, India
Nashik, Maharashtra, India
Pune City, Maharashtra, India
Surat, Gujarat, India
Sault Ste. Marie, Ontario, Canada
Vina Del Mar, , Chile
Lublin, , Poland
Namur, , Belgium
Monterrey, Nuevo Leon, Mexico
Ankara, , Turkey
Hershey, Pennsylvania, United States
Bratislava, , Slovakia
Frankfurt, , Germany
Torrette Di Ancona, Marche, Italy
Florence, Toscana, Italy
Temuco, , Chile
Olomouc, , Czechia
Sarajevo, , Bosnia And Herzegovina
Napoli, Campania, Italy
Greeley, Colorado, United States
Xitun Dist., , Taiwan
Kyiv, , Ukraine
Palma De Mallorca, , Spain
Rozzano (Mi), Lombardia, Italy
Warszawa, , Poland
Hanoi, , Vietnam
Hyderabad, Andhra Pradesh, India
Osijek, , Croatia
Herakleion, , Greece
Bengaluru, Karnataka, India
Suwon City, , Korea, Republic Of
Rīga, , Latvia
Steyr, , Austria
Dublin, , Ireland
Mar Del Plata, , Argentina
Aachen, , Germany
Itajai, Santa Catarina, Brazil
Girona, , Spain
Madrid, , Spain
Minsk, , Belarus
Cluj Napoca, , Romania
Lexington, Kentucky, United States
Cairo, , Egypt
Greenfield Park, Quebec, Canada
Daphne, Alabama, United States
Cheongju Si, , Korea, Republic Of
São Paulo, Sp, Brazil
Gdynia, , Poland
Lisboa, , Portugal
Porto, , Portugal
Thessaloniki, , Greece
Zagreb, , Croatia
Loures, , Portugal
Tatabánya, , Hungary
Porto Alegre, Rio Grande Do Sul, Brazil
Milano, Lombardia, Italy
Jamaica, New York, United States
Changchun City, , China
Riga, , Latvia
Liverpool, New South Wales, Australia
Taoyuan City, , Taiwan
Sydney, New South Wales, Australia
Le Mans, , France
Livorno, Toscana, Italy
Queretaro, , Mexico
Las Palmas De Gran Canaria, Las Palmas, Spain
Nantes, , France
Velbert, , Germany
Beer Sheva, , Israel
Avellino, Campania, Italy
Castellon De La Plana/Castello De La Plana, Castellon, Spain
Belo Horizonte, Mg, Brazil
Barretos, Sp, Brazil
Montpellier, , France
Trujillo, , Peru
Seville, Sevilla, Spain
Camden, New Jersey, United States
Cork, , Ireland
Antalya, , Turkey
Dnipropterovsk, , Ukraine
Belgrade, , Serbia
Bahia Blanca, , Argentina
Kitaadachi Gun, , Japan
Genova, Liguria, Italy
Valencia, , Spain
Rosario, , Argentina
Cachoeiro De Itapemirim, Es, Brazil
Ahens, , Greece
Athens, , Greece
Larissa, , Greece
Patras, , Greece
Thessaloniki, , Greece
Coruna, La Coruña, Spain
Ankara, , Turkey
Lutsk, Volhynian Governorate, Ukraine
Rosario, , Argentina
Kingswood, New South Wales, Australia
Hefei, , China
Karlsruhe, , Germany
Bern, , Switzerland
Saint Louis Park, Minnesota, United States
Linz, , Austria
Wuhan City, , China
Tainan, , Taiwan
Lleida, Lerida, Spain
Lajeado, Rio Grande Do Sul, Brazil
Taipei City, , Taiwan
Springfield, Oregon, United States
Madrid, , Spain
Charleroi, , Belgium
Nashville, Tennessee, United States
Fountain Valley, California, United States
Guadalajara, Jalisco, Mexico
Lexington, Kentucky, United States
Changsha City, , China
Hangzhou City, , China
Tianjing, , China
Wuhan City, , China
Taormina, Sicilia, Italy
Bhubaneswar, Odisha, India
Innsbruck, , Austria
Tbilisi, , Georgia
Flemington, New Jersey, United States
Gyeonggi Do, , Korea, Republic Of
Cdmx, Mexico City (Federal District), Mexico
Bydgoszcz, , Poland
Pretoria, , South Africa
Donostia, Guipuzcoa, Spain
Omsk, , Russian Federation
Seoul, , Korea, Republic Of
Fullerton, California, United States
Seoul, , Korea, Republic Of
Lexington, Massachusetts, United States
Salzburg, , Austria
Milano, Lombardia, Italy
Tbilisi, , Georgia
Zagreb, , Croatia
Miami, Florida, United States
Valencia, , Spain
Fuzhou City, , China
Jinan City, , China
Orange, California, United States
Columbus, Ohio, United States
Essen, , Germany
London, , United Kingdom
Culiacán, Sinaloa, Mexico
Murcia, , Spain
Quezon City, , Philippines
Sao Jose Do Rio Preto, , Brazil
Ioannina, , Greece
Northmead, New South Wales, Australia
Porto, , Portugal
San Luis Potosí, , Mexico
Cape Town, , South Africa
Belagavi, Karnataka, India
Brest, , France
Columbus, Ohio, United States
Hangzhou City, , China
Vadodara, Gujarat, India
Hochiminh City, , Vietnam
Guatemala, , Guatemala
Vicenza, Veneto, Italy
Gangwon Do, , Korea, Republic Of
Banja Luka, , Bosnia And Herzegovina
Guimarães, , Portugal
Vigo, Pontevedra, Spain
Huelva, , Spain
Vinnytsia, , Ukraine
St. Pölten, , Austria
Firenze, Toscana, Italy
Longmont, Colorado, United States
Praha 2, , Czechia
Montreal, Quebec, Canada
Quebec, , Canada
Siena, Abruzzo, Italy
Jerez De La Frontera, Cadiz, Spain
London, , United Kingdom
Negrar, Veneto, Italy
Madrid, , Spain
Mérida, Yucatan, Mexico
Skopje, , North Macedonia
Kagoshima, , Japan
Recife, Pe, Brazil
Puerto Montt, , Chile
Temuco, , Chile
St. Petersburg, Sankt Petersburg, Russian Federation
Galway, , Ireland
Houston, Texas, United States
Palma De Mallorca, Islas Baleares, Spain
Aguascalientes, , Mexico
Cleveland, Ohio, United States
Cluj Napoca, , Romania
Mostar, , Bosnia And Herzegovina
Panagyurishte, , Bulgaria
Waterford, , Ireland
Sarıyer/İstanbul, , Turkey
Towson, Maryland, United States
Jujuy, , Argentina
Ringwood East, Victoria, Australia
Namur, , Belgium
Caxias Do Sul, Rs, Brazil
Porto Alegre, Rs, Brazil
Guangzhou, , China
La Roche Sur Yon, , France
Dongnam Gu, Cheonan Si, , Korea, Republic Of
Oaxaca De Juárez, Oaxaca, Mexico
Taipei, , Taiwan
Istanbul, , Turkey
Kocaeli, , Turkey
Córdoba, Cordoba, Spain
Eugene, Oregon, United States
Warrnambool, Victoria, Australia
Sarajevo, , Bosnia And Herzegovina
Dublin, , Ireland
Zrenjanin, , Serbia
Graz, , Austria
Mohali, Punjab, India
Changsha City, , China
Västerås, , Sweden
Cork, , Ireland
Nanchang, Jiangxi, China
San Antonio, Texas, United States
Vijayawada, Andhra Pradesh, India
Strasbourg, , France
Porto Alegre, Rio Grande Do Sul, Brazil
Fort Worth, Texas, United States
Ciudad De Guatemala, , Guatemala
Gdynia, , Poland
Sungai Petani, Kedah, Malaysia
Ankara, , Turkey
Hollywood, Florida, United States
Ramat Gan, , Israel
Meldola, Emilia Romagna, Italy
Luzern, , Switzerland
Bottrop, , Germany
Tbilisi, , Georgia
Madrid, , Spain
Vinnytsia, Podolia Governorate, Ukraine
Berlin, , Germany
Paris, , France
Novy Jicin, , Czechia
Candiolo, Piemonte, Italy
Barranquilla, , Colombia
Split, , Croatia
Pune, Maharashtra, India
Mumbai, Maharashtra, India
St. Pölten, , Austria
Lodz, , Poland
Nashik, Maharashtra, India
Seoul, , Korea, Republic Of
Vila Nova De Gaia, , Portugal
Cholargos, , Greece
Empoli, Toscana, Italy
Mohali, , India
Nashik, Maharashtra, India
San José, , Costa Rica
Nairobi, , Kenya
Jesus Maria, , Peru
Monterrey, Nuevo Leon, Mexico
Skórzewo, , Poland
Lisbon, , Portugal
Torrance, California, United States
Erlangen, , Germany
Ramat Gan, , Israel
Roanoke, Virginia, United States
Athens, , Greece
Jönköping, , Sweden
Heroica Puebla De Zaragoza, Puebla, Mexico
Linyi City, , China
Ankara, , Turkey
Arequipa, , Peru
Plantation, Florida, United States
Flower Mound, Texas, United States
Mckinney, Texas, United States
Nanchang City, , China
Brest, , France
Manresa, Barcelona, Spain
Pretoria, , South Africa
Jerusalem, , Israel
Santiago De Compostela, La Coruña, Spain
Cork, , Ireland
Rocky Mount, North Carolina, United States
Ahmedabad, Gujarat, India
East Melbourne, Victoria, Australia
Mar Del Plata, Buenos Aires, Argentina
Batumi, , Georgia
Vila Real, , Portugal
Providencia, , Chile
Tyler, Texas, United States
Beer Sheba, , Israel
Eldoret, , Kenya
Nairobi, , Kenya
Caba, , Argentina
Columbia, Missouri, United States
Ahmadabad, Gujarat, India
Kyiv, Kiev Governorate, Ukraine
Bakersfield, California, United States
Fountain Valley, California, United States
Van Nuys, California, United States
Stamford, Connecticut, United States
Stony Brook, New York, United States
Portland, Oregon, United States
Fort Worth, Texas, United States
Mcallen, Texas, United States
Waco, Texas, United States
Buenos Aires, , Argentina
Rosario, , Argentina
Campbelltown, New South Wales, Australia
Darlinghurst, New South Wales, Australia
Northmead, New South Wales, Australia
Brisbane, Queensland, Australia
Crains, Queensland, Australia
Douglas, Queensland, Australia
Adelaide, South Australia, Australia
Hobart, Tasmania, Australia
Wendouree, Victoria, Australia
Rankweil, , Austria
St. Veit, , Austria
Belgium, , Belgium
Libramont Chevigny, , Belgium
Liege, , Belgium
Liège, , Belgium
Liège, , Belgium
Namur, , Belgium
Wilrijk, , Belgium
Banja Luka, , Bosnia And Herzegovina
Salvador/Ba, Ba, Brazil
Salvador, Ba, Brazil
Goiania, Go, Brazil
Belo Horizonte, Mg, Brazil
Porto Alegre, Pa, Brazil
Lajeado, Rs, Brazil
Porto Alegre, Rs, Brazil
Porto Alegre, Rs, Brazil
Porto Alegre, Rs, Brazil
Piracicaba, Sp, Brazil
Sao Jose Do Rio Preto, Sp, Brazil
Sao Paulo, Sp, Brazil
São Paulo, Sp, Brazil
Vancouver, British Columbia, Canada
Chicoutimi, Quebec, Canada
Montreal, Quebec, Canada
Saint Jerome, Quebec, Canada
La Serena, , Chile
Peñalolen, , Chile
Providencia, , Chile
Providencia, , Chile
Rancagua, , Chile
Santiago, , Chile
Santiago, , Chile
Talca, , Chile
Viña Del Mar, , Chile
Neijiang, , China
Moravia, , Costa Rica
San Jose, , Costa Rica
San José, , Costa Rica
San José, , Costa Rica
Turku, , Finland
Amiens, , France
Argenteuil, , France
Marseille, , France
Plérin, , France
Rennes Cedex, , France
Kutaisi, , Georgia
Tbilisi, , Georgia
Tbilisi, , Georgia
Tbilisi, , Georgia
Tbilisi, , Georgia
Tbilisi, , Georgia
Augsburg, , Germany
Berlin, , Germany
Bonn, , Germany
Cottbus, , Germany
Dresden, , Germany
Georgsmarienhutte, , Germany
Gera, , Germany
Halle, , Germany
Hannover, , Germany
Lübeck, , Germany
Marburg, , Germany
Mönchengladbach, , Germany
Ravensburg, , Germany
Saarbrücken, , Germany
Schweinfurt, , Germany
Athens, , Greece
Athina, , Greece
Faliro, , Greece
Faliro, , Greece
Marousi, , Greece
Marousi, , Greece
Patras, , Greece
Thessaloniki, , Greece
Thessaloniki, , Greece
Ciudad De Guatemala, , Guatemala
Ciudad De Guatemala, , Guatemala
Guatemala, , Guatemala
Salcajá, , Guatemala
Budapest, , Hungary
Patna, Bihar, India
Ahmadabad City, Gujarat, India
Surat, Gujarat, India
Vadodara, Gujarat, India
Amravati, Maharashtra, India
Kolhapur, Maharashtra, India
Nagpur, Maharashtra, India
Pune, Maharashtra, India
Bhubaneswar, Odisha, India
Bikaner, Rajasthan, India
Erode, Tamil Nadu, India
Madurai, Tamil Nadu, India
Lucknow, Uttar Pradesh, India
Kolkata, West Bengal, India
Kolkata, West Bengal, India
Cork, , Ireland
Limerick, , Ireland
Beer Jacob, , Israel
Roma, Emilia Romagna, Italy
Milano, Lombardia, Italy
Chuo, , Japan
Naha Shi, , Japan
Seodaemun Gu, , Korea, Republic Of
Putrajaya, Federal Territory Of Putrajaya, Malaysia
Mexicali, Baja California, Mexico
León De Los Aldama, Guanajuato, Mexico
Toluca, Mexico City (Federal District), Mexico
Heroica Puebla De Zaragoza, Puebla, Mexico
Mexico, , Mexico
Mexico, , Mexico
Eindhoven, , Netherlands
Sittard Geleen, , Netherlands
Bitola, , North Macedonia
Skopje, , North Macedonia
Bacolod City, , Philippines
Baguio City, , Philippines
Davao City, , Philippines
Manila, , Philippines
Manila, , Philippines
Pasig City, , Philippines
Quezon City, , Philippines
Gliwice, , Poland
Grudziadz, , Poland
Ostrołęka, , Poland
Lisboa, , Portugal
București, , Romania
Constanţa, , Romania
Craiova, , Romania
Kuzmolovsky, Sankt Petersburg, Russian Federation
Saint Petersburg, Sankt Petersburg, Russian Federation
St. Petersburg, Sankt Petersburg, Russian Federation
Kladovo, , Serbia
City Of Johannesburg, , South Africa
City Of Johannesburg, , South Africa
Floracliffe, , South Africa
George, , South Africa
Badalona, Barcelona, Spain
Santiago De Compostela, Burgos, Spain
Córdoba, Cordoba, Spain
Pamplona, Navarra, Spain
Pamplona, Navarra, Spain
Alicante, , Spain
Barcelona, , Spain
Granada, , Spain
Madrid, , Spain
Madrid, , Spain
Aarau, , Switzerland
Bern, , Switzerland
Bern, , Switzerland
Luzern, , Switzerland
Luzern, , Switzerland
Thun, , Switzerland
Winterthur, , Switzerland
Beitou Dist., , Taiwan
Changhua County, , Taiwan
Hsinchu City, , Taiwan
Istanbul, , Turkey
Izmir, , Turkey
Samsun, , Turkey
Seyhan/Adana, , Turkey
Yeni̇mahalle, , Turkey
Kharkiv, Kharkiv Governorate, Ukraine
Kryvyi Rih, Kherson Governorate, Ukraine
Chernihiv, Kiev Governorate, Ukraine
Chernivtsi, Kiev Governorate, Ukraine
Kyiv, Kiev Governorate, Ukraine
Kyiv, Kiev Governorate, Ukraine
Kyiv, Kiev Governorate, Ukraine
Zaporizhzhia, Kiev Governorate, Ukraine
Zhytomyr, Kiev Governorate, Ukraine
São Paulo, , Brazil
Dublin, , Ireland
Cluj Napoca, , Romania
Richmond, Virginia, United States
Sapporo Shi, , Japan
San Nicolás, , Argentina
Gainesville, Florida, United States
Savannah, Georgia, United States
Louisville, Kentucky, United States
Raleigh, North Carolina, United States
Williamsport, Pennsylvania, United States
Cordoba, , Argentina
Rosario, , Argentina
Sarajevo, , Bosnia And Herzegovina
Passo Fundo, Rs, Brazil
Valledupar, , Colombia
Bologna, Emilia Romagna, Italy
Padova, Veneto, Italy
Bratislava, , Slovakia
Las Palmas De Gran Canaria, Las Palmas, Spain
Tainan, , Taiwan
Izmir, , Turkey
Panorama, , Greece
Nashville, Tennessee, United States
Midlothian, Virginia, United States
Buenos Aires, , Argentina
Ciudad Autonoma Buenos Aires, , Argentina
Mar Del Plata, , Argentina
Recoleta, , Argentina
Viedma, , Argentina
Wien, , Austria
Guangzhou, , China
Pereira, , Colombia
Lima, , Peru
üsküdar, , Turkey
Kampala, , Uganda
Waterford, , Ireland
Hershey, Pennsylvania, United States
Cipoletti, , Argentina
Córdoba, , Argentina
San Juan, , Argentina
Hefei City, , China
Ranipet, Tamil Nadu, India
Aviano, Friuli Venezia Giulia, Italy
'S Gravenhage, , Netherlands
Warszawa, , Poland
Yekaterinburg, Sankt Petersburg, Russian Federation
Novosibirsk, , Russian Federation
Madrid, , Spain
Omaha, Nebraska, United States
Germantown, Tennessee, United States
Bariloche, , Argentina
Nanchang City, , China
Wenzhou City, , China
Sariçam, , Turkey
Iowa City, Iowa, United States
Estomba, , Argentina
Salta, , Argentina
North Sydney, New South Wales, Australia
Porto Alegre, Rs, Brazil
Santiago, , Chile
Chaidari, , Greece
Gómez Palacio, Durango, Mexico
San Luis Potosí, , Mexico
Samsun, , Turkey
Pittsburgh, Pennsylvania, United States
St Cloud, , France
Ho Chi Minh City, , Vietnam
Elmhurst, Illinois, United States
Seattle, Washington, United States
Cali, , Colombia
Chai Wan, , Hong Kong
R?Ga, , Latvia
Sariyer/Istanbul, , Turkey
Porto, , Portugal
Seoul, , Korea, Republic Of
Warszawa, , Poland
Santiago De Compostela, La Coruña, Spain
Seyhan/Adana, , Turkey
Candiolo, Piemonte, Italy
Sar?Yer/?Stanbul, , Turkey
Viedma, , Argentina
Suzhou City, , China
Guatemala, , Guatemala
Bellavista, , Peru
Gliwice, , Poland
Grudziadz, , Poland
Ostro??Ka, , Poland
Warszawa, , Poland
Guimarães, , Portugal
Lisboa, , Portugal
Bucure?Ti, , Romania
Constan?A, , Romania
Timi?Oara, , Romania
Vigo, Pontevedra, Spain
Madrid, , Spain
Istanbul, , Turkey
Izmir, , Turkey
Yenimahalle, , Turkey
Wuhan City, , China
Seyhan/Adana, , Turkey
Columbus, Ohio, United States
Cumberland, Maryland, United States
Shijiazhuang, , China
Tbilisi, , Georgia
Ratnagiri Kilminnal, Tamil Nadu, India
Alexandria, , Egypt
Mogale City, , South Africa
?ód?, , Poland
Burgas, , Bulgaria
Cairo, , Egypt
Cairo, , Egypt
Old Cairo, , Egypt
Dublin, , Ireland
Oaxaca De Juárez, Oaxaca, Mexico
Vitebsk, Vitsyebskaya Voblasts', Belarus
Ruse, , Bulgaria
Xi'an City, , China
Tbilisi, , Georgia
Kuala Lumpur, Fed. Territory Of Kuala Lumpur, Malaysia
Lima, , Peru
Lima, , Peru
Lima, , Peru
Lodz, , Poland
Nashville, Tennessee, United States
Namdong Gu, , Korea, Republic Of
Hiroshima, , Japan
Cordoba, , Argentina
Brest, Brestskaya Voblasts', Belarus
Salvador, Ba, Brazil
Alexandria, , Egypt
Mysuru, Karnataka, India
Budapest, , Hungary
Newport Beach, California, United States
Santiago De Querétaro, Queretaro, Mexico
Ciudad De México, , Mexico
Quezon City, , Philippines
Cork, , Ireland
Dublin, , Ireland
Galway, , Ireland
Madrid, , Spain
Dublin, , Ireland
Limerick, , Ireland
Kharkiv, Kharkiv Governorate, Ukraine
Heraklio, , Greece
San Juan, , Argentina
Porto Alegre, Pa, Brazil
Kosice, , Slovakia
Santiago De Compostela, La Coruña, Spain
Cordoba, , Argentina
Vina Del Mar, , Chile
Tianjin, , China
Yen?Mahalle, , Turkey
Belo Horizonte, Mg, Brazil
Split, , Latvia
Randfontein, , South Africa
Madrid, , Spain
Montreal, Quebec, Canada
Winston Salem, North Carolina, United States
Nanning City, , China
Essen, , Germany
Cheongju Si, , Korea, Republic Of
Quetzaltenango, , Guatemala
Aarau, , Switzerland
Chur, , Switzerland
Paris, , France
Ramat Gan, , Israel
Budapest, , Hungary
Nashville, Tennessee, United States
Reggio Emilia, Emilia Romagna, Italy
Miyagi, , Japan
Santiago, , Chile
Be'er Ya'akov, , Israel
Sao Paulo, , Brazil
Lynchburg, Virginia, United States
Rosario, , Argentina
Athens, , Greece
Praha, , Czechia
Sao Paulo, São Paulo, Brazil
Sorocaba, São Paulo, Brazil
Rio De Janeiro, , Brazil
Panagyurishte, , Bulgaria
Porto, , Portugal
Goiania, Goiás, Brazil
Recife, Pernambuco, Brazil
Santo Andre, São Paulo, Brazil
Porto Alegre, Pará, Brazil
Essen, , Germany
Puebla, Mexico City (Federal District), Mexico
Caxias Do Sul, Rio Grande Do Sul, Brazil
Barretos, São Paulo, Brazil
Newport Beach, California, United States
Towson, Maryland, United States
Saint Louis Park, Minnesota, United States
Harrisburg, Pennsylvania, United States
Pittsburgh, Pennsylvania, United States
El Paso, Texas, United States
Bahia Blanca, , Argentina
Bariloche, , Argentina
Buenos Aires, , Argentina
Cipoletti, , Argentina
Córdoba, , Argentina
Wollstonecraft, New South Wales, Australia
Belgium, , Belgium
Libramont, , Belgium
Salvador, Bahia, Bahia, Brazil
Salvador/Ba, Bahia, Brazil
Salvador, Bahia, Brazil
Salvador, Bahia, Brazil
Cachoeiro De Itapemirim, Espírito Santo, Brazil
Belo Horizonte, Minas Gerais, Brazil
Belo Horizonte, Minas Gerais, Brazil
Ijui, Rio Grande Do Sul, Brazil
Passo Fundo, Rio Grande Do Sul, Brazil
Porto Alegre, Rio Grande Do Sul, Brazil
Piracicaba, São Paulo, Brazil
Sao Jose Do Rio Preto, São Paulo, Brazil
Sao Paulo, São Paulo, Brazil
São Paulo, , Brazil
São Paulo, , Brazil
Burgas, , Bulgaria
Calgary, Alberta, Canada
Montreal, Quebec, Canada
Providencia, , Chile
Harbin City, , China
Hefei, , China
Linyi, , China
Nanchang, , China
Shanghai City, , China
Tianjin City, , China
Pereira, , Colombia
San José, , Costa Rica
Ostrava Poruba, , Czechia
Alexandria, , Egypt
Cairo, , Egypt
El Mansura, , Egypt
Markaz Sohag, , Egypt
Augsburg, , Germany
Athens, , Greece
Zalaegersteg, , Hungary
Bologna, Emilia Romagna, Italy
Roma, Emilia Romagna, Italy
Milano, Lombardia, Italy
Kumamoto Shi Chuo Ku, , Japan
Seongbuk Gu, , Korea, Republic Of
Songpa Gu, , Korea, Republic Of
Sarawak., Sarawak, Malaysia
Toluca, , Mexico
'S Gravenhage, , Netherlands
Skopje, , North Macedonia
Manila, National Capital Region, Philippines
Bacolod City, Western Visayas (Region Vi), Philippines
Manila, , Philippines
Manila, , Philippines
Grudziadz, , Poland
Kraków, , Poland
Bucure?Ti, , Romania
George, , South Africa
Coruna, La Coruna, Spain
Santiago De Compostela, La Coruna, Spain
Chur, , Switzerland
Luzern, , Switzerland
Thun, , Switzerland
Taipei, , Taiwan
Bangkok Noi, , Thailand
Fat?H, , Turkey
Kampala, , Uganda
Caixas Do Sul, Rio Grande Do Sul, Brazil
San José, , Costa Rica
Le Mans, , France
Tokyo, , Japan
Buzia?, Sarawak, Malaysia
Querétaro, Queretaro, Mexico
Quezon City, , Philippines
Montería, , Colombia
Caen, Calvados, France
Poznan, , Poland
Poznan, , Poland
Lisbon, Lisboa, Portugal
Craiova, , Romania
Bariloche, Río Negro, Argentina
Montpellier, Hérault, France
Baguio City, Benguet, Philippines
Santo Andre, , Brazil
Jau, , Brazil
Sorocaba, , Brazil
Cdmx, , Mexico
Goiania, , Brazil
Porto Alegre, , Brazil
Puebla, , Mexico
Barretos, , Brazil
Cachoeiro De Itapemirim, , Brazil
Piracicaba, , Brazil
Bacolod City, , Philippines
Patients applied
Trial Officials
Clinical Trials
Study Director
Hoffmann-La Roche
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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