A Combined Multidomain Intervention to Prevent Cognitive Decline Associated With Cardiovascular Risk Factors.

Launched by LOUIS BHERER · Jul 5, 2021

Keywords

ClinConnect Summary

The ACTIONcardioRisk trial is a study that aims to see how a combination of exercises and brain training can help improve thinking and memory skills in older adults who do not get much physical activity, especially those with heart health concerns. The goal is to find out if doing aerobic exercises (like walking or cycling) and strength training (like lifting weights) along with mental exercises can help keep the brain healthy as we age.

To participate, you need to be at least 60 years old and generally healthy, with good vision and hearing for your age. You should not have any serious memory problems and must be considered inactive, meaning you do not exercise much (less than 150 minutes a week). If you join this study, you can expect to engage in various exercise programs and cognitive training activities, all designed to support your overall brain health. This trial is currently looking for participants, and it’s a great opportunity to contribute to research that may help improve cognitive health in older adults.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adult aged 60 and older,
• • Normal or corrected vision and normal hearing for their age range,
• • No cognitive impairment (Mini-Mental State Examination - MMSE ≥ 25),
• • Inactive (\< 150 min of physical activity per week).
• Exclusion Criteria:
• • MMSE ≤ 24 or diagnosis of dementia,
• • Uncontrolled psychological / psychiatric condition within the past 6 months,
• • Neurological disease,
• • Severe exercise intolerance,
• • Respiratory disease (e.g., asthma, COPD),
• • Excessive alcohol consumption (\> 15 drinks/week),
• • Documented cerebral, peripheral or coronary atherosclerotic disease,
• • Chronic systolic or diastolic heart failure,
• • Symptomatic aortic stenosis,
• • Atrial fibrillation,
• • Automatic implantable defibrillator or permanent pacemaker,
• • Malignant exertional arrhythmias,
• • Non-cardiopulmonary limitation to exercise (e.g., arthritis).