Analgesic Effects of Low-dose S-ketamine in Major Spine Fusion Surgery

Launched by PEKING UNIVERSITY FIRST HOSPITAL · Jul 6, 2021

Keywords

ClinConnect Summary

This clinical trial is exploring the effects of a medication called S-ketamine on pain relief after major spine fusion surgery. Even with current pain management methods that often include opioids, many patients still experience significant pain after their surgery. The goal of this study is to see if giving S-ketamine during and after surgery can help reduce the amount of pain these patients feel.

To participate in this trial, individuals must be between 18 and 80 years old and scheduled for multi-segment spine fusion surgery. Participants will receive a patient-controlled pain management system after their surgery, which allows them to manage their own pain relief. It's important to note that certain health conditions may prevent some people from joining the study, such as severe heart or kidney problems. If you or someone you know is considering this trial, it could offer a new way to help manage post-surgery pain more effectively.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients aged between 18 and 80 years.
• • Scheduled to undergo multi-segment (≥2) spine fusion surgery.
• • Agreed to receive postoperative patient-controlled analgesia.
• Exclusion Criteria:
• • Refused to participant in this trial.
• • Poor blood pressure control in those with hypertension (BP \>160/100 mmHg in the ward).
• • Previous history of hyperthyroidism or pheochromocytoma.
• • Previous history of schizophrenia, epilepsy or Parkinson disease.
• • History of sick sinus syndrome, bradycardia (HR \<50 beat per min), or atrioventricular block of grade II or higher without pacemaker.
• • Severe heart dysfunction (New York Heart Association functional classification 4), hepatic insufficiency (Child-Pugh grade C), renal insufficiency (serum creatinine of 442 μmol/L or above, or requirement of renal replacement therapy), or ASA classification IV or above.
• • Unable to complete preoperative assessment due to severe dementia or language barrier.
• • Any other conditions that were considered unsuitable for the study participation.