Countermeasures to Circadian Misalignment

Launched by COLORADO STATE UNIVERSITY · Jul 7, 2021

Keywords

ClinConnect Summary

This clinical trial is looking at how adjusting eating habits can help people who work night shifts or have irregular schedules. Specifically, the study will test whether not eating during the body's natural night time can improve health and reduce the risk of obesity and diabetes among adults who are exposed to circadian misalignment—this means their sleep patterns are out of sync with the day-night cycle. The findings could benefit many workers like police officers, paramedics, and healthcare professionals who often have to work at odd hours.

To participate in this study, you need to be between 18 and 35 years old, have a normal weight, and generally sleep between 7 to 9.25 hours each night. The study will include an equal number of men and women. If you are interested, you should know that anyone with significant health issues, recent drug use, or a history of shift work may not be eligible. Participants will be closely monitored during the study, which aims to find effective strategies to help maintain a healthier lifestyle, even when typical sleep patterns are disrupted.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. 18-35 old; men and women; equal numbers of women and men will be included.
• • 2. Body Mass Index (BMI) between 20.0 and 24.9 ("normal" weight).
• • 3. Physical activity history: inactive to habitual moderate physical activity level
• • 4. Sleep/wake history: habitual sleep duration between 7-9.25 hours.
• • 5. Altitude history: Potential subjects must have lived at Denver altitude or higher for at least 3 months prior to inpatient stay.
• Exclusion Criteria:
• • 1. Any clinically significant medical, psychiatric, or sleep disorder
• • 2. Use of prescribed medications/supplements/illicit drugs within one month prior to study
• • 3. History of shift work in year prior to study, or travel more than one time zone in three weeks prior to study. \[NOTE: Subjects can be studied at a later date.\]
• • 4. Women with history of prior gynecological pathology, \<1 year post-partum, breast-feeding and/or pregnant.
• • 5. Non-English speakers will be excluded, as we do not have access to a translator who could rely accurate information to the participant for the consent or throughout the study.