Comparison of Atherogenic Risk Factors and Efficacy of Nutritional Treatment Among Adult Phenylketonuria Patients

Launched by UNIVERSITY MEDICAL CENTRE LJUBLJANA · Jul 9, 2021

Keywords

ClinConnect Summary

This clinical trial is studying how proper nutritional treatment can help adults with a rare metabolic disorder called phenylketonuria (PKU). PKU occurs when the body cannot break down a substance called phenylalanine, which can build up and cause serious brain damage and other health problems. The trial aims to see if a low-protein diet, along with special dietary supplements, can improve the well-being, blood results, and overall lifestyle of adults living with PKU.

To participate in this study, individuals must be over 18 years old and diagnosed with PKU or a related condition. They should be able to manage their own diet and understand the study's requirements. Participants will engage in a comprehensive treatment plan that includes both medical and nutritional support. Throughout the trial, they will fill out questionnaires and keep food diaries to help researchers analyze how different factors affect their health outcomes. The hope is that this research will lead to better dietary guidelines and reduced health complications for adults with PKU in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • The study will include subjects over the age of 18 who have PKU or hyperphenylalaninemia and are expected to have dietary treatment according to expert recommendations. A prerequisite for entering the investigation will be a signed consent to participate in the investigation and the ability of the participant to have a good understanding of the content of the research and to fully participate in the interventional dietary process.
• Exclusion Criteria:
• • The investigators will not include adult patients who do not manage their diet on their own and need caregivers due to limited cognitive abilities (patients with late-diagnosed disease and neurological consequences of the disease) or who do not want to sign an informed consent.