PRECISION-BP: Precision Chronopharamacotherapy Targeting NP-RAAS-BP Rhythm Axis

Launched by UNIVERSITY OF ALABAMA AT BIRMINGHAM · Jul 12, 2021

Keywords

ClinConnect Summary

The PRECISION-BP trial is studying how we can better treat high blood pressure in people who are obese. Obesity can lead to higher nighttime blood pressure and an increased risk of heart problems. This study focuses on understanding how certain hormones from the heart, called natriuretic peptides, work in relation to blood pressure throughout the day and night. The goal is to see if adjusting blood pressure medication to align with the body's natural rhythms can help restore normal blood pressure patterns in overweight individuals.

To participate in this study, you need to be at least 18 years old, have a body mass index (BMI) between 30 and 45, and have high blood pressure that falls within specific ranges. If you qualify, you will be part of a research group that explores new treatment options tailored to your body's needs. This study is currently recruiting participants and aims to improve health outcomes for those dealing with obesity and high blood pressure.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age more than or equal to 18 years of age
• • Body Mass Index between 30 to 45 kg/m\^2
• • Blood pressure: Systolic BP more than or equal to 130mmHg and less than or equal to 160mmHg and diastolic blood pressure more than or equal to 80mmHg and less than or equal to 100mmHg. Individuals with hypertension as per the 2017 ACC/AHA Guidelines will be eligible for enrollment
• Exclusion Criteria:
• • Age less than 18, at screening.
• • Systolic BP \<130 or \>160mmHg at baseline, or diastolic BP \<80 or \>100 mmHg at baseline
• • BMI \<30 kg/m\^2 or \>45 kg/m\^2
• • History of pulmonary hypertension
• • Have any past or present illness of cardiovascular disease including myocardial infarction, angina, cardiac arrhythmia, diabetes, stroke, TIA, or seizure.
• • Participants who are taking 3 or more classes of hypertension medications on the maximum dose or with resistant hypertension
• • History of angioedema
• • Estimated glomerular filtration rate (GFR) \< 60 ml/min/1.73 m2 (CKD-EPI equation); urine albumin creatinine ratio ≥30 mg/g
• • Hepatic Transaminase (AST and ALT) levels \>3x the upper limit of normal;
• • Significant psychiatric illness
• • Anemia (men, Hct \< 38%; women, Hct \<36%)
• • Participants working night shifts or swing shifts
• • Women who are pregnant or breastfeeding or who can become pregnant and not practicing an acceptable method of birth control during the study (including abstinence)