Adjunct Targeted Temperature Management in Acute Severe Carbon Monoxide Poisoning

Launched by WONJU SEVERANCE CHRISTIAN HOSPITAL · Jul 13, 2021

Keywords

ClinConnect Summary

This clinical trial is looking at how different temperature management strategies can affect the recovery of patients who have suffered from severe carbon monoxide poisoning, a serious condition that can affect brain function. The study will compare two methods: one group of patients will receive a treatment called therapeutic hypothermia, which involves cooling the body to a lower temperature, while the other group will be kept at normal body temperature. Both groups will also receive hyperbaric oxygen therapy, which is a special treatment using pure oxygen to help the body heal.

To participate in this trial, individuals must be at least 19 years old and have received hyperbaric oxygen therapy within 24 hours of their carbon monoxide poisoning. They should also show signs of severe poisoning, such as being unable to respond verbally after treatment. However, those who have had a cardiac arrest before receiving the therapy, have serious pre-existing health issues, or are pregnant cannot join. Participants will be closely monitored throughout the study and will help researchers understand how to improve care for future patients with this dangerous condition.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • ≥ 19 years.
• • Patients who received HBO within 24 hours for acute CO poisoning.
• • Patients who meet the definition of ASCOP (Patients incapable verbal obey after HBO).
• • Signed informed consent prior to study entry.
• Exclusion Criteria:
• • Cardiac arrest before HBO
• • Previous neurocognitive disorders
• • Life-threatening underlying disease (ex: advanced cancer)
• • Evidence of co-ingestion of sedative or hypnotics confirmed by intravenous flumazenil administration or history taking at the emergency department
• • Absolute contraindication for TH (active severe bleeding and profound shock not controlled by vasoactive drugs)
• • No admission
• • The significant co-ingested drug levels, which are alter the consciousness, is confirmed from the drug analysis lab
• • Pregnancy
• • Burns
• • More than moderate burn or Inhalation burn
• • Burns complicated by other trauma
• • Electrical burn
• • Burns in high risk patients (Patients with chronic underlying diseases (i.e DM, ESRD, liver cirrhosis, etc) which may cause delays or aggravate the wound healing)