Gray Matter Demyelination in Primary Progressive MS at 7T

Launched by DANISH RESEARCH CENTRE FOR MAGNETIC RESONANCE · Jul 15, 2021

Keywords

ClinConnect Summary

This clinical trial is studying primary progressive multiple sclerosis (PPMS), a type of MS that affects about 15% of people with the condition. The researchers want to understand how gray matter in the brain is damaged in PPMS, as this damage can impact movement and other functions. They are using a special type of MRI called 7 Tesla MRI, which provides very detailed images of the brain, to look closely at the gray matter and identify any damage. This study hopes to find new ways to monitor and possibly treat PPMS by understanding the brain's ability to repair itself.

To participate in this trial, individuals must be diagnosed with primary progressive MS and have a certain level of disability, but they should not have had a relapse in the last three months. Healthy volunteers are also needed for comparison, but they should not have any neurological conditions or implanted medical devices. Participants will undergo MRI scans, which are safe and non-invasive, and they should be comfortable in enclosed spaces. Overall, this research aims to uncover important information about PPMS and improve future treatments for those affected.

Gender

ALL

Eligibility criteria

• • PATIENTS
• Inclusion Criteria:
• • Diagnosed with primary progressive multiple sclerosis
• • Expanded Disability Status Scale of ≤ 6.5
• • No clinical relapse within last three months
• • Have the ability to comply with all requirements of the study protocol, as determined by the investigator
• Exclusion Criteria:
• • Pregnancy
• • Pacemaker or other implanted electronic devices
• • Claustrophobia
• • Psychiatric disorder
• • Administration of acute cortisol
• • Changes in pharmacological treatment within the last 3 months
• • Any contraindication to MRI
• • Persons who do not wish to be informed about abnormal findings as part of the investigations
• • HEALTHY CONTROLS
• Inclusion Criteria:
• • Able bodied
• • Have the ability to comply with all requirements of the study protocol, as determined by the investigator
• Exclusion Criteria:
• • Pregnancy
• • Under medication at the time of the experiment (with the exception of contraceptive drugs)
• • History of neurologic disease
• • Pacemaker or other implanted electronic devices
• • History of cerebral hemorrhage or brain damage
• • Claustrophobia
• • Psychiatric disorder
• • Any contraindication to MRI
• • Persons who do not wish to be informed about abnormal findings as part of the investigations