A Multi-Center Diagnostic Stewardship Program to Improve Respiratory Culture Utilization in Critically Ill Children
Launched by JOHNS HOPKINS UNIVERSITY · Jul 28, 2021
Trial Information
Current as of November 07, 2025
Enrolling by invitation
Keywords
ClinConnect Summary
BrighT STAR is a national, observational study in pediatric intensive care units (PICUs) to see if a structured program that guides how respiratory tests are used can safely reduce unnecessary testing and antibiotic use in critically ill children. The study will involve about 10–15 participating children’s hospitals across the United States and will compare outcomes from before the program is put in place to after it starts, looking at safety and effectiveness, including deaths, infections, and how long children stay in the ICU.
Hospitals choose to participate by planning and implementing a quality-improvement program to reduce respiratory culture use in their PICUs. The study collects data from ICU patients at these hospitals and is not testing a new drug or device. The main goal is to determine whether careful testing and antibiotic use can be reduced without harming patients. Researchers will track outcomes such as how often respiratory cultures are done, antibiotic days, ICU length of stay, readmissions, and rates of ventilator-associated infections, sepsis, and septic shock.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Institutions that plan to develop and implement a quality improvement program to reduce respiratory culture use in their Pediatric ICUs
- Exclusion Criteria:
- • Institutions that do not plan to develop and implement a quality improvement program to reduce respiratory culture use in their Pediatric ICUs
About Johns Hopkins University
Johns Hopkins University, a prestigious research institution located in Baltimore, Maryland, is renowned for its commitment to advancing medical science and public health through innovative clinical trials. With a rich history of groundbreaking research and a multidisciplinary approach, the university's clinical trial initiatives focus on translating scientific discoveries into effective treatments and interventions. Leveraging state-of-the-art facilities and a collaborative network of experts, Johns Hopkins University conducts rigorous clinical studies that aim to improve patient outcomes and address critical health challenges. Its dedication to ethical standards and participant safety underscores its role as a leader in clinical research.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Boston, Massachusetts, United States
Baltimore, Maryland, United States
Austin, Texas, United States
Memphis, Tennessee, United States
Nashville, Tennessee, United States
Omaha, Nebraska, United States
Minneapolis, Minnesota, United States
Cleveland, Ohio, United States
Patients applied
Trial Officials
Aaron Milstone, MD, MHS
Principal Investigator
Johns Hopkins University
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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