Correlation Between Cognition and Neuroimaging in TIA Patients

Launched by UNIVERSITY HOSPITAL, CAEN · Aug 2, 2021

Keywords

ClinConnect Summary

This clinical trial, called the Cog-TIA program, is studying how a transient ischemic attack (TIA)—often referred to as a "mini-stroke"—might affect thinking and memory over time. Researchers want to find out if TIAs cause long-lasting changes in the brain that can lead to difficulties with cognitive skills, even when brain scans show no major damage. Understanding how TIAs influence brain health is important because many people experience cognitive issues after such events, and this study aims to clarify the relationship between brain changes and cognitive performance.

To participate in this trial, individuals must be over 60 years old and have experienced a TIA, defined as temporary neurological symptoms lasting less than 24 hours. Participants will undergo brain scans and cognitive tests at 1 and 3 years after the TIA to assess any changes. The study is not yet recruiting, but it is essential to know that individuals with certain neurological conditions or those unable to consent will not be included. This research could provide valuable insights into brain health after TIAs and help improve care for those affected.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Transient ischemic accident Group
• • Patient over 60 years of age with a transient ischemic attack (focal neurological deficit of less than 24 hours without ischemic injury on diffusion MRI performed in the week following the event.)
• • Patient having signed a free and informed consent to participate in the Normandy-Stroke cohort.
• • Control group
• • Subject over 60 years old
• • Subject included in the Medit-AGEING research protocol
• • Subject with one or more risk factor (s) for cerebrovascular disease
• • Subject not opposing the use of their data for the Cog-Tia study
• • Non inclusion criteria
• • Transient ischemic accident Group
• • Patient with contraindications to performing a brain MRI
• • Neurological co-morbidity (history of severe head trauma, dementia, brain tumor, stroke, psychosis)
• • Refusal to participate in the Normandy-Stroke cohort
• • Persons deprived of their liberty by a judicial or administrative decision, persons undergoing psychiatric care, persons admitted to a health or social establishment for purposes other than that of research
• • Adult persons subject to a legal protection measure or unable to express their consent
• • Control group
• • - Subject refusing to the use of their data for the Cog-Tia study
• Exclusion Criteria:
• • New stroke during the study participation