Diagnostic and Prognostic Biomarkers for High-impact Chronic Pain: Development and Validation

Launched by STANFORD UNIVERSITY · Jul 29, 2021

Keywords

ClinConnect Summary

This clinical trial is focused on understanding chronic musculoskeletal pain, which is pain that lasts for a long time and affects the muscles and joints. The main goal is to find specific markers in the body that can help doctors identify whether someone is likely to recover from their pain or if they will continue to experience significant pain and difficulty with daily activities. Researchers believe that by studying these markers, they can improve how chronic pain is diagnosed and treated.

To participate in this study, adults aged 18 to 80 who have chronic musculoskeletal pain are being recruited. However, people with certain conditions, like those related to inflammatory diseases, significant brain impairment, or plans for surgery during the study, will not be eligible. Participants can expect to undergo assessments that may include interviews and tests to help researchers gather information about their pain and overall health. This trial is an important step in finding better ways to help those suffering from long-lasting pain.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1) Inclusion criteria: Adults (18-80 years; \~64% female expected based on clinic distribution) with chronic MSP as categorized by the World Health Organization (WHO).
• Exclusion Criteria:
• • 1) Chronic musculoskeletal pain (MSP) explained by inflammatory disease (e.g., rheumatoid arthritis, lupus) or CP with a primary diagnosis other than chronic MSP (e.g., neuropathic pain), (2) significant cognitive impairment, (3) MRI contraindication, (4) medical or psychiatric problems interfering with the study, (5) current medicolegal factors (e.g., open disability claim), (6) plans for surgery during the study, (7) pregnancy and (8) Children under the age of 18 will not be included in the study.