APOE in the Predisposition to, Protection From, and Prevention of Alzheimer's Disease

Launched by BANNER HEALTH · Jul 29, 2021

Keywords

ClinConnect Summary

This clinical trial is looking at how changes in the brain are linked to Alzheimer’s disease, which affects memory and thinking skills. Researchers want to understand these changes better so they can find new ways to prevent or delay the onset of Alzheimer’s symptoms. The study is currently recruiting participants aged 50 to 90 years who are in good health and can take part in various assessments, including brain scans and blood tests.

To be eligible, you should be cognitively unimpaired, meaning you do not show signs of memory or thinking problems. Participants will undergo health checks, brain imaging (like MRI and PET scans), and provide blood and spinal fluid samples for research. It’s important to note that individuals with certain health conditions or those who are pregnant cannot participate. If you join, you’ll be contributing to important research that may help others in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Male or female age 50 to 90 years old in good general health with no diseases expected to interfere with the study.
• • Willing to undergo health and cognitive assessments, brain imaging sessions (MRI and PET), and collection and banking of blood with venipuncture and CSF by lumbar puncture for genetic research, biomarker research, and DNA banking.
• • Determined to be cognitively unimpaired by PI (mechanisms may include verbal interview, participant or study partner reports or specific scores on cognitive assessments)
• Exclusion Criteria:
• • Participants with significant health issues or medical diseases that may interfere with participation, including infectious diseases that pose a risk to study personnel.
• • For PET or MRI: Female participant who is pregnant, lactating, or of childbearing potential without a negative pregnancy test or being two years postmenopausal or surgically sterile.
• • For MRI: Any contraindication for MRI including, but not limited to, pacemaker, aneurysm clips, artificial heart valves, ear implants, metal fragments or foreign objects in the eyes, skin, or body.
• • For CSF collection: Medical or surgical contraindication for lumbar puncture (e.g. on anti-coagulant therapy or had prior lumbar spinal surgery).