Impact of Obesity, Chronic Kidney Disease and Type 2 Diabetes on Human Urinary Stem Cells

Launched by HOSPICES CIVILS DE LYON · Aug 2, 2021

Keywords

ClinConnect Summary

This clinical trial is studying how obesity, chronic kidney disease, and type 2 diabetes affect special cells called urine stem cells (USC). These cells are found in urine and may help detect early signs of kidney damage, especially in people who are obese. The researchers believe that changes in these stem cells can show whether someone is at risk for kidney problems before any symptoms appear. By understanding these changes, the trial aims to find a new, non-invasive way to monitor kidney health in patients.

To participate in the trial, individuals need to be between 18 and 60 years old and not have diabetes. There are specific criteria for different groups based on weight and kidney function, such as having a certain body mass index (BMI) or kidney function levels. Participants will provide urine samples to collect these stem cells, and the researchers will analyze them for changes related to obesity and kidney health. This study offers hope for better ways to identify and monitor kidney issues early, which could lead to more effective management and treatment.

Gender

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Eligibility criteria

• Inclusion Criteria - For all participants :
• • Age between 18 and 60
• • Non diabetic (fasting blood glucose \<1.26 g/L)
• • Patient not having objected to participating in the research
• • Inclusion Criteria - For the obese group with normal renal function
• • eDFG ≥ 60 ml/min/1.73 m2
• • BMI \> 30 kg/m2
• • Microalbuminuria / creatinuria ≤ 3mg / mmol and / or proteinuria \< 0.15 g/24h
• • Inclusion Criteria - For the obese group with impaired renal function
• • eDFG \< 60 ml/min/1.73 m2
• • BMI \> 30 kg/m2
• • Microalbuminuria / creatinuria ≤ 3mg / mmol and / or proteinuria \< 0.15 g/24h
• • Inclusion Criteria - For the non-obese group with impaired renal function
• • eDFG \< 60 ml/min/1.73 m2
• • BMI between 18 and 30 kg/m2
• • Microalbuminuria / creatinuria ≤ 3mg / mmol and / or proteinuria \< 0.15 g/24h
• • Inclusion Criteria - For the non-obese group with normal renal function (control group)
• • eDFG ≥ 60 ml/min/1.73 m2
• • BMI between 18 and 30 kg/m2
• • Microalbuminuria / creatinuria ≤ 3mg / mmol and / or proteinuria \< 0.15 g/24h
• Exclusion Criteria - For all participants :
• • Acute renal failure within 3 months (defined as an increase of more than 50% in usual creatinemia)
• • Inflammatory, infectious, cardiovascular or progressive neoplastic disease
• • Urinary pathology (malformation, infection, etc.)
• • Exclusion period of a previous study or already participating in a clinical research protocol having an impact on the judgment criteria of the study