Muscle Catabolism and Outcomes in Children Following Cardiac Surgery

Launched by BOSTON CHILDREN'S HOSPITAL · Aug 3, 2021

Keywords

ClinConnect Summary

This clinical trial is studying how muscle breakdown (catabolism) affects children with congenital heart disease (CHD) after they have heart surgery. Researchers want to find out how much muscle mass these children lose during the first week after surgery and how this loss relates to their ability to function, as measured by a special score, at the time of discharge and during follow-up visits at 6 and 12 months. By understanding these changes, the goal is to help doctors find ways to prevent muscle loss and improve recovery outcomes for these young patients.

To participate in the study, children must be between 3 months and 18 years old, have a diagnosis of CHD, and be undergoing a specific type of heart surgery called biventricular conversion. Participants will undergo a series of ultrasound tests to measure their muscle mass at various points during their hospital stay and follow-up visits. The trial is currently recruiting, and researchers are collecting information about the children’s health, nutrition, and medications to better understand how these factors may influence muscle recovery after surgery. This study aims to make a difference in the long-term health and quality of life for children with CHD.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. children \> 3 months and \< 18 years old,
• • 2. diagnosed with CHD, and
• • 3. undergoing biventricular conversion.
• Exclusion Criteria:
• • 1. diagnosis of muscular dystrophy or myopathy,
• • 2. lower extremity injury or infection during the current hospitalization,
• • 3. enrolled in a concurrent nutritional intervention trial, or
• • 4. admitted for palliative care.