Prophylactic Antibiotics Useful With Antibiotic Impregnated External Ventricular Drains (EVDs)?

Launched by MONTEFIORE MEDICAL CENTER · Aug 3, 2021

Keywords

ClinConnect Summary

This clinical trial is studying the use of antibiotics in patients who need an External Ventricular Drain (EVD) due to conditions like bleeding in the brain or fluid buildup. Specifically, it's looking at whether giving antibiotics for just 24 hours is enough, or if they should be given for the entire time the EVD is in place. The goal is to find out the best way to prevent infections while using these drains.

To be eligible for this study, participants need to be at least 18 years old and have a diagnosis that requires an EVD. This includes patients with specific types of brain hemorrhages. However, people who have had recent brain surgery, are pregnant, or have certain infections won't be able to join. If someone participates, they will either receive antibiotics for just one day or for the whole duration of their EVD treatment. It's important to know that this study is currently recruiting participants, and it aims to help improve care for patients who need EVDs in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • patients over the age of 18 years and patients diagnosed with a subarachnoid hemorrhage, intracerebral hemorrhage or acute ischemic stroke who require an EVD for management of their underlying condition.
• • In certain cases (a small minority), an EVD must be replaced due to failure (i.e.; blood clot interrupting flow). In such cases, patients will be re-dosed with antibiotics prior to catheter exchange in typical fashion, and continue in their previously randomized treatment group.
• Exclusion Criteria:
• • patients who underwent any intracranial procedure in the 30 days prior,
• • patients who were on antibiotics within the week prior to admission,
• • patients with leukopenia (\<5000) at baseline,
• • patients with signs of meningitis, ventriculitis or any other infection at presentation,
• • patients who are pregnant or prisoners.
• • patients aged \< 18 years old