Restricted or Liberal Antibiotics After Appendectomy - Denver Health

Launched by DENVER HEALTH AND HOSPITAL AUTHORITY · Aug 4, 2021

Keywords

ClinConnect Summary

This clinical trial, called "Restricted or Liberal Antibiotics After Appendectomy," is looking at how the amount of antibiotics given after surgery for appendicitis affects patients. Researchers want to find out if using fewer antibiotics can help reduce side effects while still keeping patients safe. The trial is open to adults aged 18 and older who are scheduled for surgery to remove their appendix, whether the condition is simple or more complicated, like a perforated appendix.

If you participate, you will be part of a study that helps researchers understand the best antibiotic approach after your surgery. To join, you need to have a way for the medical team to contact you after your hospital stay. However, certain individuals, like those who are pregnant, have severe immune issues, or are still receiving treatment for other serious conditions, won't be eligible. The goal of this study is not only to improve patient care but also to ensure that your recovery is as smooth as possible.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age ≥ 18 years
• • Planned appendectomy (laparoscopic or open) for simple or complicated (perforated or gangrenous) appendicitis
• • Working telephone number or reliable method to contact patient after hospital discharge
• Exclusion Criteria:
• • Unable to consent
• • Pregnant Women
• • Prisoners
• • Immunocompromised as determined by clinical team, or patients actively receiving steroids, chemotherapy, or immunosuppressing medications (for example tacrolimus), or patients with active hematologic malignancy affecting the immune system, leukopenia, or end-stage AIDS
• • Heart failure
• • Allergy to bupivacaine
• • Unlikely to comply with treatment or follow-up
• • Inpatient consultation for appendicitis
• • Clinically suspected of sepsis based on Sepsis-3 definition
• • Current use of antibiotics for other indications
• • Uncontrolled hyperglycemia or Type 1 Diabetes
• • Surgeon preference
• • Patient preference
• • Research team unavailable