Laser Photocoagulation of Communicating Vessels in Twin-to-Twin Transfusion Syndrome

Launched by SEATTLE CHILDREN'S HOSPITAL · Aug 16, 2021

Keywords

ClinConnect Summary

This clinical trial is looking at a treatment for a condition called Twin-to-Twin Transfusion Syndrome (TTTS), which can occur in pregnancies where twins share a single placenta. In TTTS, one twin (the recipient) can receive too much blood, while the other twin (the donor) doesn’t get enough. The study is testing a procedure using a laser to treat the blood vessels that connect the twins, with the goal of improving health outcomes for both the mother and the babies.

To participate in this trial, women must be pregnant with twins who share a placenta, and there must be specific signs of TTTS, such as one twin having too much amniotic fluid and the other having too little. Participants can expect to receive the laser treatment and be closely monitored throughout the process. This study is currently recruiting participants, so if you or someone you know fits the criteria and is interested in helping advance medical knowledge in this area, it could be a great opportunity.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Single placenta (Monochorionic)
• • Polyhydramnios present in recipient twin (Greater than 8 cm maximum vertical pocket below 20 weeks and greater than a 10 cm pocket for greater than 20 weeks gestational age)
• • Oligohydramnios present in donor twin (Less than 2 cm maximum vertical pocket)
• • Prominent bladder in the recipient/ non-filling bladder in the donor
• • Thin dividing membrane
• Exclusion Criteria:
• • Patients unwilling to participate in the study or to be followed up
• • Presence of major congenital anomalies incompatible with survival
• • Active pre-term labor Ruptured membranes
• • Chorioamnionitis
• • Vaginal bleeding