TBS,TMS, Suicidal Ideation, Magnetic Resonance Imaging, Dorsolateral Prefrontal Cortex, Ventrolateral Prefrontal Cortex

Launched by CHANG GUNG MEMORIAL HOSPITAL · Aug 17, 2021

Keywords

ClinConnect Summary

This clinical trial is studying a treatment called Transcranial Magnetic Stimulation (TMS), which is a noninvasive method that uses magnetic fields to stimulate specific areas of the brain. The focus is on helping older adults over 50 who are struggling with major depressive disorder (MDD) and have thoughts of suicide. If you or a loved one has major depression, scores high on a suicide risk scale, and is right-handed, you might be eligible to participate. However, there are some important criteria to consider, such as not having dementia or a current severe mental crisis, and being able to provide informed consent.

Participants in the trial can expect to receive TMS treatment, which involves sessions where a device will gently stimulate the brain. The goal is to see if this treatment can help reduce symptoms of depression and suicidal thoughts. It's important to note that individuals with certain medical conditions, those taking specific medications, or anyone with a history of seizures may not be eligible. This trial is currently recruiting participants, and it aims to find effective treatments for late-life depression to improve the lives of older adults.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Age \> 50 years.
• • 2. Major depressive disorder (MDD).
• • 3. Right handiness
• • 4. with a score ≥ 12 on the Beck Scale of Suicidal Ideation (BSSI) and a score of at least 3 on Question #3 (Suicide: 3 ideas and gestures of suicide) of the HAMD
• Exclusion Criteria:
• • 1. Inability to provide informed consent.
• • 2. Dementia, as defined by MoCA 23/24. Other major mental or current psychotic symptoms
• • 3. Active current suicidal intent as evidenced or the endorsement of an actual attempt, interrupted attempt,
• • 4. Have known preexisting noise-induced hearing loss, concurrent treatment with ototoxic medications, or with cochlear implants are on medications known to lower seizure threshold.
• • 5. Alcohol or other substances abuse of or dependence on within the past 3 months Organic brain, head trauma,
• • 6. Elevated risk of seizure due to TBI
• • 7. Participation in concurrent clinical trial
• • 8. Non-correctable clinically significant sensory impairment (i.e., cannot hear well enough to cooperate with interview).
• • 9. Unstable medical illness, including delirium, malignancy, uncontrolled diabetes mellitus, hypertension, hyperlipidemia, or cerebrovascular or cardiovascular risk factors that are not under medical management. Unstable cardiac disease or recent (\<3m) myocardial infarction
• • 10. Mental implement in the brain, claustrophobia
• • 11. Ever received ECT, TMS Consent procedures.