High Dose Testosterone for ATM, CDK12 or CHEK2 Altered Prostate Cancers

Launched by VA OFFICE OF RESEARCH AND DEVELOPMENT · Aug 11, 2021

Keywords

ClinConnect Summary

This clinical trial is exploring whether high doses of testosterone can help men with certain types of advanced prostate cancer that have specific genetic changes. The focus is on patients whose cancer has alterations in genes called ATM, CDK12, or CHEK2, which may make their tumors more likely to respond to this therapy. Researchers want to see if using testosterone in a controlled way can lead to improvements in these patients’ conditions.

To be eligible for the trial, participants must be men over 18 years old with confirmed advanced prostate cancer that has not responded to at least one prior treatment. They should also be on hormone therapy to lower their testosterone levels and have certain genetic mutations identified through testing. Participants will receive high doses of testosterone on a specific schedule and will need to attend regular study visits. This trial is currently recruiting, and it's important for interested individuals to discuss their eligibility with their doctor to understand more about the potential benefits and risks involved.

Gender

MALE

Eligibility criteria

• Inclusion Criteria:
• • Signed informed consent form (ICF) providing agreement to adhere to the dosing schedule, report for all trial visits and authorization, use and release of health and research trial information
• • Male age \> 18 years
• • Histologically or cytologically confirmed adenocarcinoma of the prostate
• • Ongoing gonadal androgen deprivation therapy with gonadotropin-releasing hormone (GnRH) analogues, antagonists or orchiectomy. Patients who have not had an orchiectomy must be maintained on effective GnRH analogue/antagonist therapy
• * Castration resistant prostate cancer as defined by serum testosterone \< 50 ng/ml and one of the following:
• • PSA level of at least 2 ng/ml that has risen on at least 2 successive occasions at least 1 week apart.
• • Evaluable disease progression by modified RECIST 1.1 (Response Evaluation Criteria in Solid Tumors)
• • Progression of metastatic bone disease on bone scan with \> 2 new lesions
• • Presence of metastatic disease on bone or CT scan
• • Patients must have progressed on 1 next-generation AR-signaling inhibitor (e.g. abiraterone, enzalutamide, apalutamide, darolutamide, etc.).
• • Asymptomatic or minimal cancer related symptoms
• • Eastern Cooperative Oncology Group (ECOG) Performance Status of \< 2
• • Presence of inactivating mutations in ATM, CDK12 or CHEK2 as determined by a CLIA level assay for DNA sequencing.
• Exclusion Criteria:
• • Currently receiving active therapy for other neoplastic disorders will not be eligible.
• • Histologic evidence of small cell carcinoma (morphology alone - immunohistochemical evidence of neuroendrocrine differentiation without morphologic evidence is not exclusionary)
• • Known parenchymal brain metastasis
• • Liver metastases
• • Active or symptomatic viral hepatitis or chronic liver disease AST or ALT \> 2.5 x ULN or total bilirubin \> ULN (unless Gilbert's syndrome is the etiology of hyperbilirubinemia).
• • Clinically significant heart disease as evidenced by myocardial infarction, or arterial thrombotic events in the past 6 months, severe or unstable angina, or New York Heart Association (NYHA) Class II-IV heart disease or cardiac ejection fraction measurement of \<35 % at baseline
• • Patients with pain attributable to their prostate cancer and requiring the use of opioids.
• • Tumor causing urinary outlet obstruction that requires catheterization for voiding. Patients that require catheterization to void secondary to benign strictures or other non-cancer causes will be permitted to enroll.
• • Presence of dementia, psychiatric illness, and/or social situations limiting compliance with study requirements or understanding and/or giving of informed consent.
• • Any condition(s), medical or otherwise, which, in the opinion of the investigators, would jeopardize either the patient or the integrity of the data obtained.