Immunometabolic Mechanisms of Blood Flow Restriction (BFR) Training After Anterior Cruciate Ligament Reconstruction

Launched by YALE UNIVERSITY · Aug 12, 2021

Keywords

ClinConnect Summary

This clinical trial is studying how a technique called blood flow restriction (BFR) training can affect healing and recovery after surgery to repair the anterior cruciate ligament (ACL) in the knee. The researchers want to understand how BFR training influences the immune system and gene activity in people who are going through rehabilitation after their surgery. This study is currently looking for participants who are between 18 and 60 years old, in good overall health, and willing to attend two study visits at least one week apart.

If you choose to participate, you’ll be involved in a crossover study, which means you may experience both the BFR training and standard rehabilitation methods. However, there are some important criteria to keep in mind. You cannot have serious health conditions, such as heart problems or diabetes, and you should not have any injuries or issues with your legs that could complicate your recovery. If you meet the eligibility requirements, this trial could provide you with insights into a new approach to support your healing journey after ACL surgery.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Provision of signed and dated informed consent form
• • 2. Stated willingness to comply with all study procedures and availability for two study visits at least 1 week apart
• • 3. All genders, between 18 and 60 years of age
• • 4. In good general health without any underlying medical conditions or prior injury that would place the subject at risk of further injury/illness by participating in the study
• Exclusion Criteria:
• • 1. Serious medical conditions including cardiovascular, metabolic (diabetes), rheumatologic, pulmonary, or musculoskeletal.
• • 2. Multiple ligament ruptures or trauma
• • 3. Rheumatoid arthritis or other significant comorbidities
• • 4. Lower extremity vascular pathology, including history of deep vein thrombosis
• • 5. Those with a history of sickle cell trait or disease
• • 6. Use of anticoagulant medications
• • 7. Pregnancy
• • 8. Treatment with another investigational drug or other intervention within one month of Study Day 1
• • 9. Current smoker or tobacco use within 3 months of Study Day 1
• • 10. Febrile illness within 2 weeks of Study Day 1