Kidney Sodium Functional Imaging

Launched by LONDON HEALTH SCIENCES CENTRE RESEARCH INSTITUTE OR LAWSON RESEARCH INSTITUTE OF ST. JOSEPH'S · Aug 14, 2021

Keywords

ClinConnect Summary

This clinical trial, called "Kidney Sodium Functional Imaging," is studying how kidney function is affected in people with different types of kidney diseases, including chronic kidney disease (CKD), kidney stones, and polycystic kidney disease (ADPKD). Researchers want to see if a special imaging technique called sodium Magnetic Resonance Imaging (MRI) can help them understand changes in how the kidneys handle salt and water. This information could help improve the care and management of patients with kidney problems.

To participate in the study, individuals need to be at least 18 years old. Healthy volunteers are welcome, but they should not have any kidney disease or related health issues. Patients with CKD must have a specific measure of kidney function that indicates their condition. Those on dialysis for more than three months can also join. However, some people may not be eligible if they are pregnant, have certain medical devices in their body, or cannot undergo an MRI due to size or anxiety. Participants will undergo non-invasive MRI scans of their kidneys, which means they won't need any surgery or invasive procedures. This study could provide valuable insights into kidney health and help improve treatments for kidney disease.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age ≥ 18 years
• • For healthy controls: lack of kidney disease, heart failure, liver cirrhosis and peripheral edema
• • For CKD stage 1-5: Estimated GFR \< 90 mL/min/1.73m²
• • For patients on maintenance hemodialysis or peritoneal dialysis: more than 3 months duration of therapy
• Exclusion Criteria:
• • Pregnant, breastfeeding or intending pregnancy
• • Contraindication to MRI
• • Inability to tolerate MRI due to patient size and/or known history of claustrophobia.
• • Mechanically implanted, electrically, or magnetically activated device or any metal in their body which cannot be removed, including but not limited to pacemakers, neurostimulators, biostimulators, implanted insulin pumps, aneurysm clips, bioprosthesis, artificial limb, metallic fragment or foreign body, tattoos, shunt, surgical staples (including clips or metallic sutures and/or ear implants.)