A Study to Learn About the Study Medicine Elranatamab Alone and With Daratumumab in People With Multiple Myeloma Who Have Received Other Treatments
Launched by PFIZER · Aug 18, 2021
Trial Information
Current as of June 27, 2025
Recruiting
Keywords
ClinConnect Summary
The MagnetisMM-5 clinical trial is studying a new treatment option for people with relapsed or refractory multiple myeloma, a type of blood cancer. Researchers want to see if a medication called elranatamab, which targets specific cancer cells, is more effective when given alone or in combination with another drug called daratumumab, compared to a standard treatment that includes daratumumab, pomalidomide, and dexamethasone. This study aims to find out which treatment works best and is safest for patients who have already tried other therapies.
To participate in this study, individuals must have a confirmed diagnosis of multiple myeloma, measurable disease, and must have previously received treatments that include lenalidomide and a proteasome inhibitor. Participants will receive treatment until their disease worsens, they experience unacceptable side effects, or they decide to leave the study. Everyone who joins will be closely monitored for their health and how well the treatments work. If you're interested, it’s important to discuss with your doctor to see if you meet the eligibility criteria and if this trial is a good option for you.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Prior diagnosis of multiple myeloma as defined by IMWG criteria (Rajkumar et al, 2014).
- * Measurable disease based on IMWG criteria as defined by at least 1 of the following:
- • Serum M-protein ≥0.5 g/dL.
- • Urinary M-protein excretion ≥200 mg/24 hours.
- • Serum immunoglobulin FLC ≥10 mg/dL (≥100 mg/L) AND abnormal serum immunoglobulin kappa to lambda FLC ratio (\<0.26 or \>1.65).
- • Prior anti-multiple myeloma therapy including treatment with lenalidomide.
- • ECOG performance status ≤2.
- • Resolved acute effects of any prior therapy to baseline severity or CTCAE Grade ≤1.
- • Not pregnant and willing to use contraception.
- Exclusion Criteria:
- • Smoldering multiple myeloma.
- • Plasma cell leukemia.
- • Amyloidosis.
- • POEMS Syndrome.
- • Stem cell transplant within 12 weeks prior to enrolment, or active graft versus host disease.
- • Active HBV, HCV, SARS-CoV2, HIV, or any active, uncontrolled bacterial, fungal, or viral infection.
- • Any other active malignancy within 3 years prior to enrolment, except for adequately treated basal cell or squamous cell skin cancer, or carcinoma in situ.
- • Previous treatment with a BCMA-directed therapy.
- • Live attenuated vaccine within 4 weeks of the first dose of study intervention.
- • Administration with an investigational product (e.g. drug or vaccine) concurrent with study intervention or within 30 days preceding the first dose of study intervention used in this study.
About Pfizer
Pfizer Inc. is a global leader in biopharmaceutical innovation, dedicated to discovering, developing, and delivering advanced therapies that enhance patient outcomes across a wide range of medical conditions. With a rich history of scientific research and a commitment to quality, Pfizer focuses on areas such as oncology, immunology, cardiology, and rare diseases. The company leverages cutting-edge technology and collaborates with healthcare professionals, regulatory bodies, and academic institutions to conduct rigorous clinical trials that ensure the safety and efficacy of its products. Pfizer's mission is to bring breakthroughs that change patients' lives, exemplifying its commitment to health and wellness worldwide.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Edmonton, Alberta, Canada
Dallas, Texas, United States
New Orleans, Louisiana, United States
Greenslopes, Queensland, Australia
Clovis, California, United States
Halifax, Nova Scotia, Canada
Miami, Florida, United States
Calgary, Alberta, Canada
Melbourne, Victoria, Australia
Salamanca, , Spain
Woolloongabba, Queensland, Australia
Montreal, Quebec, Canada
Madrid, , Spain
New Orleans, Louisiana, United States
Geelong, Victoria, Australia
Santander, Cantabria, Spain
Cardiff, South Glamorgan, United Kingdom
Cardiff, , United Kingdom
Sendai, Miyagi, Japan
Fukuoka, , Japan
Bournemouth, Dorset, United Kingdom
Taipei, , Taiwan
Paris, , France
Hamamatsu, Shizuoka, Japan
Taichung, , Taiwan
Sevilla, , Spain
Yamagata, , Japan
Tainan, , Taiwan
Oxford, Oxfordshire, United Kingdom
Akita, , Japan
Barcelona, , Spain
Valencia, , Spain
Richmond, Victoria, Australia
Hamilton, , New Zealand
Seoul, , Korea, Republic Of
Seoul, , Korea, Republic Of
Seoul, , Korea, Republic Of
Santa Fe, New Mexico, United States
Bristol, , United Kingdom
Toyohashi, Aichi, Japan
Yoshida Gun, Fukui, Japan
Sunto Gun, Shizuoka, Japan
Tokushima, , Japan
Girona, , Spain
Falun, , Sweden
Barcelona, , Spain
Halifax, Nova Scotia, Canada
Manchester, , United Kingdom
Guangzhou, Guangdong, China
Nagasaki, , Japan
Gdansk, , Poland
Berlin, , Germany
Changchun, Jilin, China
Jinan, Shandong, China
Nagoya, Aichi, Japan
Okayama, , Japan
Fresno, California, United States
Ulm, , Germany
Miami, Florida, United States
Richmond, Victoria, Australia
München, , Germany
Hradec Kralove, , Czechia
Incheon, , Korea, Republic Of
Tianjin, Tianjin, China
Toronto, Ontario, Canada
Fukuoka, , Japan
Shijiazhuang, Hebei, China
Chemnitz, , Germany
Taipei, , Taiwan
örebro, , Sweden
Pamplona, Navarra, Spain
Wuhan, Hubei, China
Beijing, Beijing, China
Daegu, , Korea, Republic Of
Auckland, , New Zealand
Göteborg, , Sweden
Maastricht, , Netherlands
Wien, , Austria
Würzburg, Bayern, Germany
Fuzhou, Fujian, China
Zhengzhou, Henan, China
Charleroi, Hainaut, Belgium
Metairie, Louisiana, United States
Shenzhen, Guangdong, China
Bydgoszcz, , Poland
Harbin, Heilongjiang, China
Pune, Maharashtra, India
Seongnam Si, Gyeonggi Do, Korea, Republic Of
Nedlands, Western Australia, Australia
Paris Cedex 12, , France
Nanchang, Jiangxi, China
Wroclaw, , Poland
Madrid, , Spain
Cordoba, , Spain
Fitzroy, Victoria, Australia
Canterbury, , United Kingdom
Buenos Aires, , Argentina
Fresno, California, United States
Busan, , Korea, Republic Of
Greenslopes, Queensland, Australia
Luleå, , Sweden
Guangzhou, Guangdong, China
Wenzhou, Zhejiang, China
Kumamoto, , Japan
Hangzhou, Zhejiang, China
Ostrava Poruba, , Czechia
Nantes Cedex 1, , France
Olomouc, , Czechia
Auckland, , New Zealand
Tainan, , Taiwan
Palmerston North, Manawatu, New Zealand
Clovis, California, United States
Linköping, , Sweden
Xuzhou, Jiangsu, China
Auckland, , New Zealand
Aachen, , Germany
Shibuya Ku, Tokyo, Japan
Gaziantep, , Turkey
Braunschweig, , Germany
Roma, , Italy
Praha 2, , Czechia
Terrassa, Barcelona, Spain
Jinan, Shandong, China
Katowice, , Poland
Salzburg, , Austria
Kagoshima, , Japan
Chongqing, , China
Athens, , Greece
Osaka, , Japan
Ankara, , Turkey
New Delhi, Delhi, India
Palmerston North, , New Zealand
Terrassa, Barcelona, Spain
Harrison, New York, United States
Turku, Varsinais Suomi, Finland
Santiago De Compostela, A Coruna, Spain
Perth, Western Australia, Australia
Roma, , Italy
Roma, Lazio, Italy
Papatoetoe, Auckland, New Zealand
Gurugram, Haryana, India
Benowa, Queensland, Australia
Lund, , Sweden
Seoul, Seoul Teukbyeolsi [Seoul], Korea, Republic Of
Milano, Lombardia, Italy
Trondheim, , Norway
Wroclaw, , Poland
São Paulo, , Brazil
Saskatoon, Saskatchewan, Canada
Adana, , Turkey
Istanbul, , Turkey
Rotterdam, Zuid Holland, Netherlands
Rosario, Santa Fe, Argentina
New Delhi, Delhi, India
Seoul, Seoul Teukbyeolsi [Seoul], Korea, Republic Of
İzmir, İ̇zmir, Turkey
Beijing, Beijing, China
Malatya, , Turkey
Athens, , Greece
Bologna, , Italy
Busan, Pusan Kwangyǒkshi, Korea, Republic Of
Skorzewo, , Poland
Ioannina, , Greece
New York, New York, United States
Krems, , Austria
Fort Collins, Colorado, United States
Nantes, , France
Greeley, Colorado, United States
Gilly, Hainaut, Belgium
Vienna, Wien, Austria
Kaohsiung, , Taiwan
Coral Gables, Florida, United States
Tampere, Pirkanmaa, Finland
Oaxaca, , Mexico
Stavanger, Rogaland, Norway
Oslo, , Norway
Richmond, Victoria, Australia
Pierre Benite Cedex, , France
Yahaba Cho, Shiwa Gun, Iwate, Japan
Poznan, , Poland
Santa Fe, New Mexico, United States
Changchun, Jilin, China
Porto Alegre, Rio Grande Do Sul, Brazil
Siena, Toscana, Italy
Middletown, New Jersey, United States
Montvale, New Jersey, United States
Uniondale, New York, United States
Krems, Niederösterreich, Austria
Yvoir, Namur, Belgium
Hamilton, Ontario, Canada
Guangzhou, Guangdong, China
Tianjin, Tianjin, China
Beijing, , China
Oulu, Pohjois Pohjanmaa, Finland
Helsinki, , Finland
Lille, Nord, France
Poitiers, Vienne, France
Athens, Attikí, Greece
Athens, Attikí, Greece
Athens, Attikí, Greece
Thessaloniki, Kentrikí Makedonía, Greece
Vellore, Tamil Nadu, India
Genova, Liguria, Italy
Catania, Sicilia, Italy
Shibukawa, Gunma, Japan
Shiwa Gun Yahaba Cho, Iwate, Japan
Hwasun Gun, Jeonranamdo, Korea, Republic Of
Seoul, Seoul Teukbyeolsi [Seoul], Korea, Republic Of
Daegu, Taegu Kwangyǒkshi, Korea, Republic Of
Bydgoszcz, , Poland
L'hospitalet Del Llobregat, Barcelona [Barcelona], Spain
Girona, Girona [Gerona], Spain
Toledo, Other, Spain
Gerona, , Spain
Madrid, , Spain
Helsingborg, , Sweden
Lund, , Sweden
Borås, , Sweden
örebro, , Sweden
Linköping, , Sweden
İstanbul / şişli, İ̇stanbul, Turkey
Istanbul, İ̇stanbul, Turkey
İstanbul, İ̇stanbul, Turkey
Istanbul, İ̇stanbul, Turkey
İzmir, İ̇zmir, Turkey
Ankara, , Turkey
Antalya, , Turkey
Aydin, , Turkey
Kocaeli, , Turkey
Monterrey, Nuevo León, Mexico
São Paulo, , Brazil
Basking Ridge, New Jersey, United States
Loveland, Colorado, United States
East Melbourne, Victoria, Australia
Ulm, Baden Württemberg, Germany
İstanbul, İ̇stanbul, Turkey
Kayseri, , Turkey
Veracruz, , Mexico
Halifax, Nova Scotia, Canada
Poitiers Cedex, , France
Roslyn, , New Zealand
Porto Alegre, Rio Grande Do Sul, Brazil
Commack, New York, United States
New York, New York, United States
Ciudad Autonoma De Buenos Aires, Buenos Aires, Argentina
Ciudad Autónoma De Buenos Aires, Buenos Aires, Argentina
Ciudad Autónoma De Buenos Aires, Buenos Aires, Argentina
Plzen Lochotin, Plzeňský Kraj, Czechia
Warszawa, , Poland
Bergen, Hordaland, Norway
Derqui, Pilar, Buenos Aires, Argentina
Derqui, Pilar, Buenos Aires, Argentina
Richmond, Victoria, Australia
Vienna, Wien, Austria
Köln, Nordrhein Westfalen, Germany
Berlin, , Germany
São Paulo, Sp, Brazil
Sao Paulo, São Paulo, Brazil
São Paulo, , Brazil
Milano, Milan, Italy
Rio De Janeiro, , Brazil
Ciudad Autonoma De Buenos Aires, Buenos Aires, Argentina
Rio De Janeiro, , Brazil
Rio De Janeiro, , Brazil
Pessac, Aquitaine, France
Salvador,, Bahia, Brazil
São Paulo, , Brazil
São Paulo, , Brazil
Praha, Praha 2, Czechia
Ciudad Autonoma De Buenos Aires, Buenos Aires, Argentina
Wellington, , New Zealand
Istanbul, İ̇stanbul, Turkey
Kuopio, Pohjois Savo, Finland
Poznan, , Poland
São Paulo, , Brazil
São Paulo, , Brazil
Brno, Brno M?Sto, Czechia
Vienna, Wien, Austria
Montréal, Quebec, Canada
Nanjing, Jiangsu, China
Madrid, Madrid, Comunidad De, Spain
Innsbruck, , Austria
Colonia Valle De Las Palmas, Huixquilucan, México, Mexico
Auckland, , New Zealand
Monza, Lombardia, Italy
Bologna, , Italy
Headington, Oxford, United Kingdom
Jinan, Shandong, China
La Plata, Buenos Aires, Argentina
Yvoir, Namur, Belgium
Muenchen, , Germany
Limoges, Limousin, France
Meldola, Emilia Romagna, Italy
Hamm, , Germany
Oxford, Oxfordshire, United Kingdom
Clayfield, Queensland, Australia
Porto Alegre, Rio Grande Do Sul, Brazil
Seoul, , Korea, Republic Of
Aventura, Florida, United States
Coral Springs, Florida, United States
Deerfield Beach, Florida, United States
Hollywood, Florida, United States
Miami, Florida, United States
Plantation, Florida, United States
Fort Collins, Colorado, United States
Sp, São Paulo, Brazil
Santa Fe, New Mexico, United States
Santa Fe, New Mexico, United States
São Paulo, , Brazil
Toulouse, , France
Athina, Attikí, Greece
Hamilton, , New Zealand
Hamilton, , New Zealand
Newtown, Wellington, , New Zealand
Takapuna, Auckland, , New Zealand
İzmir, , Turkey
Salvador, Bahia, Brazil
Thessaloniki, , Greece
Istanbul, , Turkey
İzmir, , Turkey
Sao Paulo, , Brazil
São Paulo, , Brazil
Athens, , Greece
Brisbane, Queensland, Australia
Tianjin, Tianjin, China
Auckland, , New Zealand
Milford, Auckland, , New Zealand
Metairie, Louisiana, United States
Linköping, , Sweden
Calgary, Alberta, Canada
Calgary, Alberta, Canada
Ankara, , Turkey
Yahaba Cho, Iwate, Japan
Derqui, Buenos Aires, Argentina
Colonia Valle De Las Palmas, México, Mexico
Milford, , New Zealand
Newtown, , New Zealand
Takapuna, , New Zealand
Monterrey, , Mexico
Brno, , Czechia
İstanbul, , Turkey
Sp, , Brazil
Plzen Lochotin, , Czechia
Praha, , Czechia
Athina, , Greece
Colonia Valle De Las Palmas, , Mexico
L'hospitalet Del Llobregat, , Spain
Linköping, , Sweden
İstanbul, , Turkey
Patients applied
Trial Officials
Pfizer CT.gov Call Center
Study Director
Pfizer
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
Similar Trials