Enhancing Gait Using Alternating-Frequency DBS in Parkinson Disease
Launched by JAMES LIAO · Aug 19, 2021
Trial Information
Current as of June 26, 2025
Recruiting
Keywords
ClinConnect Summary
This clinical trial is studying a new way to help people with Parkinson's disease improve their balance and walking. Researchers are looking at a technique called alternating-frequency Deep Brain Stimulation (DBS), which involves sending electrical signals to specific parts of the brain. The goal is to see if this method can reduce problems like unsteady walking and falling, while also helping with other motor symptoms of Parkinson's.
To participate in this study, individuals need to be between the ages of 21 and 70, already have an implanted Medtronic Percept PC DBS system, and experience issues with balance or walking. Participants should be able to walk without assistance when off their medication. The trial is currently recruiting and is open to all genders. If you join, you can expect to undergo assessments related to your walking and balance, and there will be video recordings of your visit to help researchers analyze the results. This trial could provide valuable insights into improving treatment for Parkinson's disease.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Bilateral STN DBS for PD
- • Medtronic Percept PC implanted DBS battery/pulse generator/recording system
- • Presence of balance and/or walking impairment and/or freezing of gait
- • Can walk without assistance, OFF meds, based on yes/no verbal response
- Exclusion Criteria:
- • Severity of gait impairment should not require dependency to walker or cane
- • Cannot tolerate monopolar stimulation at either of the two middle electrode contacts (prerequisite for the recording mode of the DBS) at high frequency (130 Hz) or low frequency (60 Hz).
- • Concomitant conditions that may affect significantly the evaluation of balance or gait, including orthopedic, rheumatologic or other neurological diseases
- • Contraindication to physical therapy
- • Age \< 21
- • Diagnosis of dementia
- • Not agreeable to having video taken of entire research visit
About James Liao
James Liao is a distinguished clinical trial sponsor known for his commitment to advancing medical research and innovation. With a robust background in biomedical sciences and a proven track record in managing and overseeing clinical trials, Liao focuses on developing cutting-edge therapies that address unmet medical needs. His collaborative approach emphasizes integrity, transparency, and adherence to regulatory standards, ensuring the safety and efficacy of new treatments. Through strategic partnerships and a patient-centered philosophy, James Liao plays a pivotal role in driving forward the landscape of clinical research.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Cleveland, Ohio, United States
Patients applied
Trial Officials
James Liao, MD PhD
Principal Investigator
The Cleveland Clinic
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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