Can MRI of the Prostate Combined With a Radiomics Evaluation Determine the Invasive Capacity of a Tumour

Launched by NOVA SCOTIA HEALTH AUTHORITY · Aug 26, 2021

Keywords

ClinConnect Summary

This clinical trial is investigating how well an advanced MRI scan, combined with a special computer program, can help doctors understand how aggressive prostate cancer is. Prostate cancer is the most common cancer in men in Canada, and being able to assess its severity accurately can lead to better treatment decisions. The goal is to improve the way MRI scans are interpreted, making them more reliable for predicting the behavior of the cancer.

To join this study, participants must be male and have had a specific type of MRI and biopsy that confirms the presence of prostate cancer. The MRI must have been performed recently and show a detectable tumor. Participants will need to lie still during the MRI scan, and certain past medical procedures or conditions that affect the prostate may exclude them from the trial. Those who take part will help researchers learn more about using MRI to better manage prostate cancer, potentially leading to improved care for future patients.

Gender

MALE

Eligibility criteria

• Inclusion Criteria:
• An appropriate diagnostic MRI-P, defined as:
• • Being performed on 3T MRI at the Halifax Infirmary Building
• • Taken place within 5 weeks of study enrolment
• • Having a detectable nodule which anatomically localizes to prostate cancer (PCa) identified in diagnostic biopsy specimen
• • Acquired T1+contrast, T2, and attenuated diffusion coefficient (ADC) series axial images of the prostate
• An appropriate diagnostic biopsy, defined as:
• • Taken place within 2 months of the participant's MRI-P 1
• • Taken place within 3 months of participant's study enrolment
• • Reports diagnosis of PCa
• • Reports a systematic assessment of the biopsy, assessing at least 12 cores
• • Reports at least on core involved with PCa and this core must anatomically localise to a nodule seen on MRI-P 1
• Exclusion Criteria:
• • Past prostatic interventions which would influence the prostate's structure
• • Alterations to physiological testosterone levels
• • Inability to position one's self in a reproducible fashion for an MRI-P
• • Patient factors reported to produce significant artifact on MRI-P 1