Fitness and Lung Function Among Survivors of Heart Transplant, Leukemia and Infant BPD Through Exercise

Launched by MASONIC CANCER CENTER, UNIVERSITY OF MINNESOTA · Aug 23, 2021

Keywords

ClinConnect Summary

This clinical trial is focused on understanding how exercise affects the heart and lung function in young survivors of certain chronic conditions, including those who have survived acute lymphoblastic leukemia (ALL), have chronic lung disease from being premature, or have received a heart transplant. The goal is to find out more about why some individuals may have difficulty exercising and to do this in a way that does not involve invasive procedures.

To participate in this study, you need to be between 8 and 25 years old, at least 48 inches tall, and able to walk on your own. You must also speak English and have certain health conditions, such as being a survivor of ALL who has finished treatment at least three months prior or living with chronic lung disease or having had a heart transplant. If you qualify, you will undergo assessments that will help researchers learn about your exercise capacity and the health of your lungs and heart. This trial is not yet recruiting participants, but it aims to provide important insights into the health of young individuals with these conditions.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• * Cases:
• • Acute lymphoblastic leukemia survivor, OR living with chronic lung disease of prematurity, OR living with heart transplant
• • 8-25 years old
• • Height: ≥ 48 inches
• • Ambulatory without assistance
• • English speaking
• • Normotensive (\<95th percentile for age; okay if managed with antihypertensive medication)
• • SpO2 \>92%
• • Not pregnant
• • ALL survivor specific: must have completed therapy ≥ 3 months prior to study entry
• • Controls
• • 8-25 years old
• • Height: ≥ 48 inches
• • Ambulatory without assistance
• • English speaking
• • No history of arrhythmia or known cardiac dysfunction at baseline
• • Normotensive (\<95th percentile for age; okay if managed with antihypertensive medication)
• • SpO2 \>95%
• • Not pregnant
• Exclusion Criteria:
• * Cases:
• • ALL specific: received cranial radiation, bone marrow transplant recipients
• • Investigator or patient's primary physician deems the patient unsuitable for the study
• * Controls:
• • History of malignancy, CLD or HT or any other diagnosis which may reduce cardiorespiratory function
• • Investigator deems the patient unsuitable for the study