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Search / Trial NCT05027854

Brain Network Mechanisms Causally Underlying Human Decisions Revealed by Brain Stimulation and Functional MRI

Launched by CHRISTIAN RUFF · Aug 23, 2021

Trial Information

Current as of June 26, 2025

Not yet recruiting

Keywords

ClinConnect Summary

This clinical trial is looking at how stimulating certain areas of the brain affects our behavior and brain activity. Researchers will use techniques called transcranial magnetic stimulation (TMS) and transcranial electric stimulation (tES) to see how changes in brain activity can influence our decision-making and behavior. The goal is to better understand the connection between the brain and how we act in everyday situations.

To participate, you need to be between 18 and 80 years old and generally right-handed. However, the study will mostly recruit younger adults, aged 18 to 40. There are some reasons why someone might not be eligible, like having certain medical devices in the body, a history of seizures, or significant brain injuries. If you join the study, you can expect to undergo non-invasive brain stimulation and participate in activities that help researchers learn more about how our brains work during decision-making. It's important to note that this trial is not yet recruiting participants, so keep an eye out for updates if you're interested.

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • between 18 and 80 years of age (whereby for most studies the majority of recruited participants will be between 18 and 40 years of age)
  • right-handedness and/or one specific gender (male or female) can be inclusion criteria to reduce variation in the data.
  • Exclusion Criteria:
  • inability to understand the instructions and insufficient knowledge of the project language
  • Internal electronic and/or metallic objects in the head, neck, or shoulders (e.g. artificial cochleae, deep brain stimulators, medical pumps, shrapnel, metallic splinters due to accidents during metal welding)
  • One or more epileptic fits in the participant or a first-degree relative
  • Vascular, traumatic, tumoral, infectious, or metabolic brain damage
  • Use of medication that significantly alters cortical excitability
  • Acute sleep deprivation or withdrawal from alcohol
  • pregnancy
  • to reduce bias, students of psychology or economics can be excluded if there is a possibility that they are familiar with the relevant paradigm.

About Christian Ruff

Christian Ruff is a distinguished clinical trial sponsor known for his innovative contributions to the field of medical research, particularly in cardiovascular health and behavioral science. With a strong background in clinical epidemiology and a commitment to advancing patient care, Ruff leads multidisciplinary teams in conducting rigorous clinical trials that aim to evaluate new therapeutic interventions and improve treatment outcomes. His work emphasizes the integration of real-world evidence and patient-centered approaches, fostering collaborations that bridge academia and industry to enhance the understanding of complex health conditions. Through his leadership, Ruff has significantly impacted the landscape of clinical research, striving to translate scientific discoveries into practical applications that benefit diverse patient populations.

Locations

Patients applied

0 patients applied

Trial Officials

Christian Ruff, PhD

Principal Investigator

University of Zurich

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

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