Cerebral Autoregulation in Patients With Symptomatic Cerebral Atherosclerotic Stenosis

Launched by YI YANG · Aug 29, 2021

Keywords

ClinConnect Summary

This clinical trial is studying how well the brain regulates its blood flow in patients with narrowing of the arteries in the brain, specifically those who have recently experienced a stroke or transient ischemic attack (TIA). The researchers want to understand the relationship between this blood flow regulation and the chances of having another stroke. They plan to enroll about 850 participants to find out what levels of blood flow regulation are linked to a higher risk of stroke recurrence.

To be eligible for this study, participants should be between 18 and 80 years old and have a significant narrowing (50-99%) in one of the main arteries supplying blood to the brain. They should have had a stroke or TIA within the last 30 days and have a good level of function before the event. Participants must be able to cooperate during tests and give their consent to join the study. Those who have certain other medical conditions or are undergoing specific treatments will not be able to participate. If you join the study, you can expect to undergo assessments to measure your brain's blood flow regulation and receive support throughout the process.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age ranging from 18 to 80, both genders
• • Unilateral internal carotid artery (ICA) or M1 segment of middle cerebral artery (MCA) stenosis (rate of stenosis ranging from 50-99%)
• • Acute ischemic cerebrovascular events (TIA or ischemic stroke) within cerebral stenotic artery supplying area
• • Onset of disease \<30 d before enrollment
• • Modified Ranking Scale (mRS) ≤1 before stroke onset
• • National Institutes of Health Stroke Scale (NIHSS) ≤20
• • Sufficient bilateral temporal bone windows for insonation of the middle cerebral artery
• • Be conscious, and able to cooperate with CA assessment
• • Willing to participate and sign the informed consent
• Exclusion Criteria:
• • Vertebral artery (VA), basilar artery (BA), anterior cerebral artery (ACA), or posterior cerebral artery (PCA) stenosis; Bilateral internal carotid artery (ICA) or M1 segment of middle cerebral artery (MCA) stenosis(rate of stenosis ranging from 50-99%)
• • Patients who have received or plan to undergo intravascular interventional treatment/endarterectomy
• • Other intracranial diseases, including cerebral hemorrhage (primary or secondary), intracranial neoplasm, aneurysm, arteriovenous malformation, etc.
• • Evidence for embolic stroke, such as atrial fibrillation, prosthetic valve surgery, and suspected endocarditis, etc.
• • Arrhythmia, anemia and hyperthyroidism which may influence the stability of cerebral blood flow diagnosed by two physicians by electrocardiogram and laboratory tests.
• • Dementia, severe anxiety, depression, and other mental diseases
• • Malignant neoplasm and expected lifetime \<2 years
• • Enrolled in other clinical trails within 6 months