Arginine + Citrulline as a Supplement for Weight Gain in Fetus With a Decrease in Their Growth Curve

Launched by HOSPITAL CIVIL DE GUADALAJARA · Aug 27, 2021

Keywords

ClinConnect Summary

50 patients with a pregnancy of more than 26 weeks of gestation, 25 with intervention and 25 control will be included; in which the fetus is between 10 and 25th percentile . It will be carried out in the obstetric service of the old civil hospital, with a double-blind randomization.

Evaluations will be carried out every two weeks where the fetal weight, umbilical artery Doppler, middle cerebral artery, venous duct, uterine arteries, amniotic fluid, placenta will be evaluated.

The assessment will be made until birth, from where the birth weight, height, Apgar, Capurro score, characteristic...

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Pregnancy with a single fetus
• • Patient over 18 years of age
• • Patient under 35 years of age
• • Pregnancy greater than 25 weeks' gestation confirmed by first trimester ultrasound or reliable last period
• • Fetus with decrease or flattening of its growth curve by ultrasound (P\> 10 and \<25)
• • Apparently healthy fetus
• • Fetus without Doppler alterations in any of its blood vessels (Venous Ductus, Cerebral Artery medial, Umbilical Artery .
• Exclusion Criteria:
• • Fetus diagnosed with a malformation
• • Fetus diagnosed with a syndrome or chromosomopathy
• • Fetus below the 10th percentile for gestational age by ultrasound
• • Mother with Type 1, Type 2 or Gestational Diabetes mellitus.
• • Chronic maternal hypertension
• • Preeclampsia with data of severity or early onset
• • Aspirin intake (100-150 mg a day from the first trimester of pregnancy)
• • Fetus with a poor ultrasonographic window for evaluation.
• • Mother with BMI \<18.5 prior to pregnancy
• • Maternal BMI\> 30
• • Known allergy to treatment
• • Non-reassuring fetal state.
• • Abnormal placental insertion.
• • Patient with renal insufficiency, LUPUS or Antiphospholipid syndrome