Optimising Ventilation in Preterms With Closed-loop Oxygen Control

Launched by KING'S COLLEGE HOSPITAL NHS TRUST · Aug 25, 2021

Keywords

ClinConnect Summary

This clinical trial is studying how a special computer program, called 'closed-loop automated oxygen control' (CLAC), can help premature infants breathe better while they are on a ventilator. Many premature babies need help with breathing, and while ventilators can save lives, they can also cause problems for the lungs and other organs. This study aims to see if using the automated system can reduce the time these infants spend on the ventilator compared to when a medical team adjusts the oxygen levels manually. The hope is that CLAC will not only help maintain the right oxygen levels but also allow babies to stop using the ventilator sooner, which could lead to fewer complications.

To participate in this trial, infants must be less than 31 weeks old at birth and need mechanical ventilation within the first 48 hours after birth. Unfortunately, babies born at or after 31 weeks, or those with serious birth defects, cannot join. If eligible, participants can expect to have their oxygen levels monitored closely with this new system to help researchers understand its effectiveness. Overall, this study could provide valuable insights into improving care for premature infants who need respiratory support.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Preterm infants less than 31 weeks completed gestation at birth requiring mechanical ventilation and admitted to King's NICU in the first 48 hours after birth
• Exclusion Criteria:
• • Preterm infants above 31 weeks completed gestation or term born infants
• • Infants with major congenital abnormalities