Function of Platelets Used for Transfusions

Launched by SOFIA RAMSTRÖM · Sep 2, 2021

Keywords

ClinConnect Summary

This is an observational study in adults with blood cancers who are getting treatment and need platelet transfusions because their platelet counts are low. Researchers want to learn how transfused platelets behave in the body, especially how well they raise the platelet count and how platelets become activated. To study this, they will take a small sample from the platelet concentrate before it’s transfused and test it with a flow cytometry method to look at activation markers and different platelet subtypes. They will measure the corrected count increment (CCI)—a way to see how much the platelet count increases after transfusion—at 1 hour and 24 hours, along with other signs of how well the transfusion works.

About 240 adults at two Swedish hospitals (Örebro and Linköping) are expected to participate. Eligible people are adults 18 or older with malignant hematologic disorders who are undergoing cancer treatment and need a platelet transfusion; those requiring HLA-matched platelets are not included. Participants will receive platelet transfusions as part of routine care. The study will collect information on infections, fever, bleeding, how many platelet transfusions are given, and how many days pass until the next transfusion after the study platelets are used, with follow-up for up to about two weeks. This is not a test of a new drug or treatment, and results are not yet available. Data from the study may be shared in a de-identified form after publication to help other researchers, under a controlled process.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Participant undergoing treatment for malignant hematologic disorders
• • Thrombocytopenia
• • Require platelet transfusion
• Exclusion Criteria:
• • - Participant requiring HLA-matched platelet transfusions.