Hyperpolarized 129-Xenon Imaging in Adult Hematopoietic Cell Transplant Recipients With Pulmonary Impairment

Launched by M.D. ANDERSON CANCER CENTER · Sep 2, 2021

Keywords

ClinConnect Summary

This clinical trial is looking at a special type of imaging called hyperpolarized 129-Xenon MRI to better understand lung issues in patients who have received a stem cell transplant (also known as hematopoietic cell transplant). Specifically, the study aims to see how well this imaging technique can measure lung function and blood flow in patients who have developed a condition called bronchiolitis obliterans syndrome (BOS), as well as those with some lung problems but not fully meeting the criteria for BOS. The researchers will also check if the imaging can help predict if a patient's lung condition will worsen over the next six months.

To be eligible for the trial, participants need to be adults aged 18 or older who have had a stem cell transplant and either have BOS, early signs of lung impairment (BOS stage 0p), or chronic graft-versus-host disease affecting organs other than the lungs. The study is currently recruiting participants and will include some healthy volunteers to help calibrate the imaging equipment. Participants can expect to undergo advanced imaging tests at MD Anderson Cancer Center, and those with certain health issues or who are unable to return for follow-up care may not qualify.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • - Allo-HCT recipients who are at least 18 years of age and have BOS (n=10 patients), BOS 0p (n = 10 patients), or cGVHD of a non-lung organ without evidence of pulmonary impairment (n = 5 patients).
• Healthy Cohort - Inclusion Criteria:
• • We will perform only XeMRI imaging on 10 healthy adult (18 years and older) volunteers with no medical issues for technical calibration of the XeMRI technology. Members of the study team may serve as healthy volunteers if they have no prior history of lung disease. These data will not be included as part of the analysis.
• Exclusion Criteria:
• • 1. Participants unable to follow up at MD Anderson for routine clinical care
• • 2. Inability or unwillingness to give informed consent
• • 3. Relapsed disease or life expectancy less than 6 months at time of enrollment
• • 4. Severe claustrophobia precluding MRI imaging
• • 5. Active pulmonary infection
• • 6. Pregnant women