Cold Snare Endoscopic Mucosal Resection (EMR) vs Cold EMR With Margin Snare Tip Soft Coagulation (STSC)

Launched by WESTERN SYDNEY LOCAL HEALTH DISTRICT · Sep 2, 2021

Keywords

ClinConnect Summary

This clinical trial is studying two different methods for removing certain types of growths in the colon called adenomas, which can sometimes lead to cancer if not treated. The trial compares a technique called cold snare endoscopic mucosal resection (EMR) with another method that combines cold snare EMR and a special soft coagulation technique to see which one is more effective for completely removing these growths that are between 15 and 40mm in size.

To participate in this trial, patients should be over 18 years old and have at least one specific type of adenoma located in the colon or rectum that meets certain characteristics. However, people who are pregnant, have bleeding disorders, or have certain other medical conditions may not be eligible. Participants can expect to undergo a colonoscopy, and the trial is currently recruiting individuals, so there may be opportunities to join soon. It's important for potential participants to discuss this option with their healthcare provider to see if they qualify.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• * Any patient undergoing colonoscopy who is older than 18 years of age, has a written consent for trial participation and has at least one laterally spreading lesion meeting the following description:
• • Localisation in the colon or rectum
• • Benign adenomatous surface features (Kudo III / IV, Japan NBI Expert Team (JNET) 2a)
• • Granular or non-granular topography
• • Paris classification 0-IIa/IIb +/- Is
• • If present, sessile component may be no greater than 10mm in size.
• • Polyp size ranging from 15 to 40mm
• Exclusion Criteria:
• • Current use of antiplatelet (excluding aspirin) or anticoagulants which have not appropriately been interrupted according to the guidelines.
• • Known bleeding disorder or coagulopathy.
• • Pregnancy
• • History of inflammatory bowel disease
• • Previously attempted or otherwise non-lifting lesions
• • Endoscopic features suggestive of submucosal invasion (Kudo Vi/n, JNET 2b / 3) or concurrent colorectal cancer
• • Lesions involving the ileocaecal valve (ICV), appendiceal oriface or anorectal junction (ARJ)