Metabolic Phenotyping and Follow-Up of Patients With and Without Diabetes After New Onset of STEMI

Launched by GERMAN DIABETES CENTER · Sep 7, 2021

Keywords

ClinConnect Summary

The DISTEMI-Study is looking at how people with and without diabetes are affected after experiencing a serious heart condition called ST-segment Elevation Myocardial Infarction (STEMI). This study will help researchers understand the differences in health and metabolism between those who have diabetes, those with prediabetes, and those with normal blood sugar levels. By examining these groups, the study aims to learn more about how the heart recovers after a STEMI and how diabetes might influence this process.

To join the study, participants need to be between 18 to 80 years old and have recently had a STEMI. They can either have diabetes, be prediabetic, or have normal glucose levels. Participants must also be stable and able to give consent. Throughout the study, participants can expect regular check-ups where their health, metabolism, and heart function will be closely monitored. This research is important because it could lead to better care for patients with different metabolic conditions after a heart event.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Condition after new onset of ST-segment elevation myocardial infarction (STEMI)
• • Age 18-80 years
• • HbA1c \<9.0%
• • People with diagnosis of diabetes mellitus according to ADA and DDG criteria (i.e. HbA1c ≥6.5% and/or pathological oral glucose tolerance test)
• • Healthy people with normal glucose tolerance status according to ADA and DDG criteria (i.e. HbA1c \<5.7% and normal OGTT)
• • People with impaired glucose metabolism ("prediabetes") according to ADA and DDG criteria (i.e. impaired fasting glucose and/or impaired glucose tolerance and/or HbA1c 5.7-6.4%)
• • Consent-able, hemodynamically stable people, without sedation (e.g. opiates) or other interfering medication (e.g. catecholamines)
• Exclusion Criteria:
• • Diabetes mellitus category 3 A-H (ADA criteria), gestational diabetes
• • Current pregnancy
• • Infectious diseases, acute infections / fever
• • Immunosuppressive therapy
• • Severe chronic renal, liver or heart disease (e.g. serum creatinin ≥1.6 mg/dl, peripheral artery occlusive disease stage IV)
• • Malignant diseases
• • Severe chronic psychiatric illness or addiction
• • Participation in an intervention trial