Effect of Local Treatment(Carrageenan Nasal Spray and PVP-I Mouthwash) in Reducing Viral Load in Patients With COVID-19

Launched by NATIONAL TAIWAN UNIVERSITY HOSPITAL · Sep 16, 2021

Keywords

ClinConnect Summary

Oral and nasal disinfection, a simple method with the application of commonly used antiseptic agents is frequently performed in the otolaryngology and dental practice. The ability to deactivate viral particles with a good safety profile may be an important benefit in the control of viral proliferation and shedding. Actually, multiple anti-septic agents demonstrated virucidal properties against SARS-CoV-2 in several in vitro studies. Among these, Povidone-Iodine (PVP-I), common usage in otolaryngology operation and topical therapy, showed high virucidal properties (0.45% PVP-I, throat spray,...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. age older than 20 years of age
• • 2. admission with a confirmed positive test for SARS-CoV-2 infection by reverse transcription polymerase chain reaction (RT- PCR)
• • 3. disease onset (start of COVID-19 symptom and PCR test) for ≤ 120 hours
• • 4. available informed consent of this study.
• • 5. Full COVID-19 vaccination(at least after 2nd dose of TFDA-approved vaccine 14 days)
• Exclusion Criteria:
• • 1. receiving oxygen supply before intervention
• • 2. known intolerance/allergy to the study drugs
• • 3. pregnancy
• • 4. sinus/oral operation within 30 days of the beginning of the study
• • 5. using intranasal medication before randomization
• • 6. no available informed consent
• • 7. inability to self-care or reply to questionnaire