DISE: Phenotyping Obstruction Patterns

Launched by UNIVERSITY OF PENNSYLVANIA · Sep 9, 2021

Keywords

ClinConnect Summary

This clinical trial, called DISE: Phenotyping Obstruction Patterns, is studying a procedure called drug-induced sleep endoscopy (DISE) to better understand how the upper airway behaves during sleep in patients with obstructive sleep apnea (OSA). The researchers want to see how different factors, like the structure of the airway and muscle function, affect airflow and breathing. By using a device that applies gentle air pressure (like a CPAP machine) during the DISE procedure, along with imaging techniques like CT scans and ultrasounds, they aim to find out what causes blockages in the airway during sleep. This information could help develop personalized treatment options for patients who struggle with sleep-related breathing issues.

To participate in this trial, adults aged 18 and older who are scheduled for a DISE procedure and are looking for alternatives to CPAP therapy may be eligible. There are no specific exclusions, so if you are interested and meet the age requirement, you can consider joining. Participants can expect to undergo the DISE procedure with additional tests that will help the researchers gather detailed information about their airway. This study aims to improve how doctors assess and treat sleep apnea, ultimately leading to better outcomes for patients.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Adults (≥ 18yrs) willing and capable of providing informed consent.
• • 2. English-speaking \& able to give Informed Consent.
• • 3. Referred or scheduled for clinically indicated DISE procedure.
• • 4. Seeking CPAP alternatives for treatment of sleep disordered breathing.
• Exclusion Criteria:
• • None